Model of pyramidal neurons that either hyper or hypo excitable due to SCN2A mutations. Mutations are taken from patients with ASD or Epilepsy
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Currents: I Na,t; I Sodium; I K
Genes: Nav1.2 SCN2A
Model Concept(s): Epilepsy; Autism spectrum disorder
Simulation Environment: NEURON; MATLAB
Implementer(s): Ben-Shalom, Roy [rbenshalom at ucdavis.edu]
References:
Ben-Shalom R et al. (2017). Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures. Biological psychiatry. 82 [PubMed]