This model includes ion concentration dynamics (sodium, potassium, chloride) inside and outside the neuron, the exchange of ions with glia and blood vessels, volume dynamics of neuron, glia, and extracellular space, glutamate homeostasis involving release by neuron and uptake by both neuron and glia. Spreading depolarization is used as a case study.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Generic; Neocortex
Cell Type(s): Astrocyte
Currents: I Potassium; I Sodium; I Cl, leak; I K,leak; I Na, leak; Na/K pump
Transmitters: Glutamate
Model Concept(s): Action Potentials; Homeostasis
Simulation Environment: XPPAUT
Implementer(s): Ullah, Ghanim [ghanim.phy at gmail.com]; Hubel, Niklas
References:
Hübel N, Hosseini-Zare MS, Žiburkus J, Ullah G. (2017). The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization. PLoS computational biology. 13 [PubMed]