"We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal Na+ spikes that provided new insights into signal processing and computational capabilities of these principal cells. Six human layer 2 and layer 3 pyramidal cells (HL2/L3 PCs) were modeled, integrating detailed anatomical and physiological data from both fresh and postmortem tissues from human temporal cortex. The models predicted particularly large AMPA- and NMDA- conductances per synaptic contact (0.88 nS and 1.31nS, respectively) and a steep dependence of the NMDA-conductance on voltage..."
Model Type: Dendrite; Axon; Neuron or other electrically excitable cell
Region(s) or Organism(s): Human; Neocortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell
Simulation Environment: NEURON (web link to model); Python (web link to model)
Implementer(s): Eyal, Guy [guy.eyal at mail.huji.ac.il]
Eyal G et al. (2018). Human Cortical Pyramidal Neurons: From Spines to Spikes via Models. Frontiers in cellular neuroscience 12 [PubMed]