Action potential-evoked Na+ influx similar in axon and soma (Fleidervish et al. 2010) (Python)

"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential-associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex U1 L5B pyramidal pyramidal tract GLU cell; Neocortex L5/6 pyramidal GLU cell

Currents: I Sodium; I Na,p; I Potassium

Model Concept(s): Action Potentials; Active Dendrites; Reaction-diffusion

Simulation Environment: NEURON; Python

Implementer(s): McDougal, Robert [robert.mcdougal at]


Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN. (2010). Na+ imaging reveals little difference in action potential-evoked Na+ influx between axon and soma. Nature neuroscience 13 [PubMed]