" ...The effects of field interactions on neuronal recruitment depend on several factors, which have been studied extensively at the macro-scale but have been overlooked in the case of high density arrays. Here, we report that field interactions can significantly affect neural recruitment, even with low amplitude stimulation. We created a computational model of peripheral nerve axons to estimate stimulation parameters sufficient to generate neural recruitment during synchronous and asynchronous stimulation on two microelectrodes located within the peripheral nerve. Across a range of stimulus amplitudes, the model predicted that synchronous stimulation on adjacent electrodes (400 µm separation), would recruit 2-3 times more neurons than during asynchronous stimulation. ..."
Model Type: Axon
Model Concept(s): Action Potentials
Simulation Environment: NEURON (web link to model); MATLAB (web link to model)
Implementer(s): Hokanson, James A. [jim.hokanson at duke.edu]
References:
Hokanson JA, Gaunt RA, Weber DJ. (2018). Effects of Synchronous Electrode Pulses on Neural Recruitment During Multichannel Microstimulation. Scientific reports. 8 [PubMed]