Cl- homeostasis in immature hippocampal CA3 neurons (Kolbaev et al 2020)

Model used for the revision of the manuscript. Insertion of a passive Cl- flux and an active Cl-accumulation. Parameters adapted to match the properties of [Cl-]i determined in immature rat CA3 neurons in-vitro.

Model Type: Neuron or other electrically excitable cell; Synapse

Region(s) or Organism(s): Hippocampus

Currents: NKCC1

Receptors: GabaA

Transmitters: Gaba

Model Concept(s): Synaptic Plasticity; Homeostasis

Simulation Environment: NEURON

Implementer(s): Jedlicka, Peter [jedlicka at]; Kilb, Werner [wkilb at]


Kolbaev SN et al. (2020). NKCC-1 mediated Cl- uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs. Scientific reports 10 [PubMed]