Model used for the revision of the manuscript. Insertion of a passive Cl- flux and an active Cl-accumulation. Parameters adapted to match the properties of [Cl-]i determined in immature rat CA3 neurons in-vitro.
Model Type: Neuron or other electrically excitable cell; Synapse
Region(s) or Organism(s): Hippocampus
Currents: NKCC1
Receptors: GabaA
Transmitters: Gaba
Model Concept(s): Synaptic Plasticity; Homeostasis
Simulation Environment: NEURON
Implementer(s): Jedlicka, Peter [jedlicka at em.uni-frankfurt.de]; Kilb, Werner [wkilb at uni-mainz.de]
References:
Kolbaev SN et al. (2020). NKCC-1 mediated Cl- uptake in immature CA3 pyramidal neurons is sufficient to compensate phasic GABAergic inputs. Scientific reports 10 [PubMed]