Increasing temperatures overwhelmingly shunts dendritic electrical spread in a crustacean motor neuron (LG) leading to the disruption of a vital pattern generator. LG recieves synaptic input from a descending projection neuron (MCN1) via a chemical and electrical synapse. Warmer temperatures increase leak conductances in the neurite and increase the synaptic input. Here, we modelled the conflicting influence of temperature at the MCN1-LG synapse and LG neurite to determine the resulting ePSP and AP amplitude measured at different distanced from the synaptic input after passive progation through the neurite.
Model Type: Dendrite
Region(s) or Organism(s): Stomatogastric ganglion
Simulation Environment: NEURON
Implementer(s): Demaegd, Maggie [mdemaeg at ilstu.edu]; Stein, Wolfgang [wstein@ilstu.edu]
References:
DeMaegd ML, Stein W. (2021). Neuropeptide modulation increases dendritic electrical spread to restore neuronal activity disrupted by temperature J Neurosci.