This computational model can account for layer-specific neuron numbers in various different cortical structures. It is agent-based and is initiated from a small homogeneous pool of precursor cells. The file Lamination.java includes the main function that induces the activation of multiple "modules" within a gene regulatory network.
Model Type: Agent-based model
Region(s) or Organism(s): Neocortex
Model Concept(s): Development
Simulation Environment: Cx3Dp
References:
Bauer R, Clowry GJ, Kaiser M. (2021). Creative destruction: a basic computational model of cortical layer formation Cerebral cortex (New York, N.Y. : 1991) 31 [PubMed]