Multicompartmental model of EP neuron was created using automatic parameter optimization. We included both short term plasticity and long term plasticity. We simulated the response to inputs from globus pallidus, striatum and subthalamic nucleus. We show that dopamine long term plasticity enhances information transmission from striatum and reduces GPe and STN information transmission.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Globus pallidus neuron
Currents: I Sodium; I Potassium; I Calcium; I CNG; IK Bkca; IK Skca; I_KD
Simulation Environment: MOOSE/PyMOOSE
Implementer(s): Blackwell, Avrama [avrama at gmu.edu]
References:
Gorodetski L et al. (2021). Endocannabinoids and Dopamine Balance Basal Ganglia Output. Frontiers in cellular neuroscience 15 [PubMed]