RA projection neurons in zebra finches display different levels of resurgent INa through development. This work reports that projection neurons in the adult zebra finch song nucleus RA display: 1) robust high-frequency firing, 2) ultra-short half-width spike waveforms, 3) superfast Na+ current inactivation kinetics and 4) large resurgent Na+ currents (INaR). Dynamic clamping provides evidence of INaR role in neuronal excitability. The model is composed by one gate with an activating and one inactivating particle which describe a transient inward current triggered by neuronal depolarization.
Model Type: Channel/Receptor
Cell Type(s): Zebra Finch RA projection neuron
Currents: I Sodium
Model Concept(s): Action Potentials; Motor control
Simulation Environment: IGOR Pro
Implementer(s): Dagostin, Andre [dagostia at ohsu.edu]
References:
Zemel BM et al. (2021). Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control Nature communications. 12 [PubMed]