Dorsal root ganglion (DRG) neuronal model (Amir, Devor 2003)

The model shows that an electrically excitable soma is not necessary for spike through-conduction in the t-shaped geometry of a dorsal root ganglion neuron axon. Electrical excitability of the soma is required, however, for soma spike invasion. See papers for details and more.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Myelinated neuron; Dorsal Root Ganglion (DRG) cell

Currents: I Na,t; I K

Model Concept(s): Activity Patterns; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials

Simulation Environment: NEURON

Implementer(s): Amir, Ron [ronamir at pob.huji.ac.il]

References:

Amir R, Devor M. (2003). Electrical excitability of the soma of sensory neurons is required for spike invasion of the soma, but not for through-conduction. Biophysical journal. 84 [PubMed]

Amir R, Devor M. (2003). Extra spike formation in sensory neurons and the disruption of afferent spike patterning. Biophysical journal. 84 [PubMed]