Jeffrey Magee and Erik Cook found evidence in experiments and modeling that support the hypothesis that an increase in synaptic conductance for synapses at larger distances from the soma is responsible for reducing the location dependence (relative to the soma) of synapses.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Receptors: AMPA
Model Concept(s): Influence of Dendritic Geometry
Simulation Environment: NEURON
Implementer(s): Magee, Jeffrey [jmagee at lsumc.edu]
References:
Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]