Fluctuating synaptic conductances recreate in-vivo-like activity (Destexhe et al 2001)

This model (and experiments) reported in Destexhe, Rudolh, Fellous, and Sejnowski (2001) support the hypothesis that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically. Some of these cortical neuron characteristics of fluctuating synaptic origin are a depolarized membrane potential, the presence of high-amplitude membrane potential fluctuations, a low input resistance and irregular spontaneous firing activity. In addition, the point-conductance model could simulate the enhancement of responsiveness due to background activity. For more information please contact Alain Destexhe. email: Destexhe@iaf.cnrs-gif.fr

Model Type: Synapse

Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell

Currents: I Na,t; I K; I M

Receptors: GabaA; AMPA

Model Concept(s): Activity Patterns; Simplified Models; Synaptic noise

Simulation Environment: NEURON

Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]

References:

Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ. (2001). Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience. 107 [PubMed]