Endothelin action on pituitary latotrophs (Bertram et al. 2006)

Endothelin (ET-1, -2, and -3 designate three genes which produce different endothelin isopeptides) is a prolactin inhibiting substance of hypothalmic origin. ET-1 binding is part of at least four G protein signaling pathways in lactotrophs. The sequence of events in these pathways following the presentation of nano- and pico-molar concentrations of ET-1 is modeled in the paper.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Pituitary cell

Currents: I K; I_SERCA

Transmitters: Amino Acids

Model Concept(s): Activity Patterns; Signaling pathways

Simulation Environment: XPP (web link to model)

References:

Bertram R, Tabak J, Toporikova N, Freeman ME. (2006). Endothelin action on pituitary lactotrophs: one receptor, many GTP-binding proteins. Science's STKE : signal transduction knowledge environment. 2006 [PubMed]