A dual-Ca2+-sensor model for neurotransmitter release in a central synapse (Sun et al. 2007)


Sun J et al. (2007). A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature. 450 [PubMed]

See more from authors: Sun J · Pang ZP · Qin D · Fahim AT · Adachi R · Südhof TC

References and models cited by this paper

Atluri PP, Regehr WG. (1998). Delayed release of neurotransmitter from cerebellar granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Awatramani GB, Price GD, Trussell LO. (2005). Modulation of transmitter release by presynaptic resting potential and background calcium levels. Neuron. 48 [PubMed]

Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH. (2000). Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter. Science (New York, N.Y.). 289 [PubMed]

Bollmann JH, Sakmann B. (2005). Control of synaptic strength and timing by the release-site Ca2+ signal. Nature neuroscience. 8 [PubMed]

Charvin N et al. (1997). Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. The EMBO journal. 16 [PubMed]

Chuhma N, Ohmori H. (2002). Role of Ca(2+) in the synchronization of transmitter release at calyceal synapses in the auditory system of rat. Journal of neurophysiology. 87 [PubMed]

Dallos P, Evans BN, Hallworth R. (1991). Nature of the motor element in electrokinetic shape changes of cochlear outer hair cells. Nature. 350 [PubMed]

Fernández-Chacón R et al. (2001). Synaptotagmin I functions as a calcium regulator of release probability. Nature. 410 [PubMed]

Forsythe ID. (1994). Direct patch recording from identified presynaptic terminals mediating glutamatergic EPSCs in the rat CNS, in vitro. The Journal of physiology. 479 ( Pt 3) [PubMed]

Geppert M et al. (1994). Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell. 79 [PubMed]

Goda Y, Stevens CF. (1994). Two components of transmitter release at a central synapse. Proceedings of the National Academy of Sciences of the United States of America. 91 [PubMed]

Grynkiewicz G, Poenie M, Tsien RY. (1985). A new generation of Ca2+ indicators with greatly improved fluorescence properties. The Journal of biological chemistry. 260 [PubMed]

Hagler DJ, Goda Y. (2001). Properties of synchronous and asynchronous release during pulse train depression in cultured hippocampal neurons. Journal of neurophysiology. 85 [PubMed]

Hefft S, Jonas P. (2005). Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse. Nature neuroscience. 8 [PubMed]

Heidelberger R, Heinemann C, Neher E, Matthews G. (1994). Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature. 371 [PubMed]

Kushmerick C, Renden R, von Gersdorff H. (2006). Physiological temperatures reduce the rate of vesicle pool depletion and short-term depression via an acceleration of vesicle recruitment. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Lou X, Scheuss V, Schneggenburger R. (2005). Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion. Nature. 435 [PubMed]

Lu T, Trussell LO. (2000). Inhibitory transmission mediated by asynchronous transmitter release. Neuron. 26 [PubMed]

Lévêque C et al. (1994). Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis. The Journal of biological chemistry. 269 [PubMed]

Maximov A, Südhof TC. (2005). Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron. 48 [PubMed]

Meinrenken CJ, Borst JG, Sakmann B. (2003). Local routes revisited: the space and time dependence of the Ca2+ signal for phasic transmitter release at the rat calyx of Held. The Journal of physiology. 547 [PubMed]

Nagy G et al. (2006). Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Otsu Y et al. (2004). Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Pang ZP et al. (2006). Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Pang ZP, Sun J, Rizo J, Maximov A, Südhof TC. (2006). Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. The EMBO journal. 25 [PubMed]

Ravin R, Spira ME, Parnas H, Parnas I. (1997). Simultaneous measurement of intracellular Ca2+ and asynchronous transmitter release from the same crayfish bouton. The Journal of physiology. 501 ( Pt 2) [PubMed]

Sakaba T, Neher E. (2001). Quantitative relationship between transmitter release and calcium current at the calyx of held synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Schneggenburger R, Forsythe ID. (2006). The calyx of Held. Cell and tissue research. 326 [PubMed]

Schneggenburger R, Neher E. (2005). Presynaptic calcium and control of vesicle fusion. Current opinion in neurobiology. 15 [PubMed]

Schneggenburger R, Wolfel M, Lou X. (2007). A mechanism intrinsic to the vesicle fusion machinery determines fast and slow transmitter release at a large CNS synapse. J Neurosci. 27

Stevens CF, Sullivan JM. (2003). The synaptotagmin C2A domain is part of the calcium sensor controlling fast synaptic transmission. Neuron. 39 [PubMed]

Stevens CF, Wesseling JF. (1998). Activity-dependent modulation of the rate at which synaptic vesicles become available to undergo exocytosis. Neuron. 21 [PubMed]

Sun J, Bronk P, Liu X, Han W, Südhof TC. (2006). Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Sun JY, Wu LG. (2001). Fast kinetics of exocytosis revealed by simultaneous measurements of presynaptic capacitance and postsynaptic currents at a central synapse. Neuron. 30 [PubMed]

Takahashi T, Iwasaki S. (1998). Developmental changes in calcium channel types mediating synaptic transmission in rat auditory brainstem. J Physiol. 509 ( Pt 2)

Taschenberger H, Scheuss V, Neher E. (2005). Release kinetics, quantal parameters and their modulation during short-term depression at a developing synapse in the rat CNS. The Journal of physiology. 568 [PubMed]

Tatsuo H, Ono N, Tanaka K, Yanagi Y. (2000). SLAM (CDw150) is a cellular receptor for measles virus. Nature. 406 [PubMed]

Trommershäuser J, Schneggenburger R, Zippelius A, Neher E. (2003). Heterogeneous presynaptic release probabilities: functional relevance for short-term plasticity. Biophysical journal. 84 [PubMed]

Wadel K, Neher E, Sakaba T. (2007). The coupling between synaptic vesicles and Ca2+ channels determines fast neurotransmitter release. Neuron. 53 [PubMed]

Wang X, Culotta VC, Klee CB. (1996). Superoxide dismutase protects calcineurin from inactivation. Nature. 383 [PubMed]

Wu LG, Westenbroek RE, Borst JG, Catterall WA, Sakmann B. (1999). Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Xu J, Mashimo T, Südhof TC. (2007). Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron. 54 [PubMed]

Zhong H, Yokoyama CT, Scheuer T, Catterall WA. (1999). Reciprocal regulation of P/Q-type Ca2+ channels by SNAP-25, syntaxin and synaptotagmin. Nature neuroscience. 2 [PubMed]

References and models that cite this paper

Keller D et al. (2015). An Exclusion Zone for Ca2+ Channels around Docked Vesicles Explains Release Control by Multiple Channels at a CNS Synapse. PLoS computational biology. 11 [PubMed]

Lee CC, Anton M, Poon CS, McRae GJ. (2009). A kinetic model unifying presynaptic short-term facilitation and depression. Journal of computational neuroscience. 26 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.