Gap-junction coupled network activity depends on coupled dendrites diameter (Gansert et al. 2007)

"... We have previously shown that the amplitude of electrical signals propagating across gap-junctionally coupled passive cables is maximized at a unique diameter. This suggests that threshold-dependent signals may propagate through gap junctions for a finite range of diameters around this optimal value. Here we examine the diameter dependence of action potential propagation across model networks of dendro-dendritically coupled neurons. The neurons in these models have passive soma and dendrites and an action potential-generating axon. We show that propagation of action potentials across gap junctions occurs only over a finite range of dendritic diameters and that propagation delay depends on this diameter. ...". See paper for more and details.

Model Type: Realistic Network; Neuron or other electrically excitable cell

Currents: I Na,t; I K

Model Concept(s): Activity Patterns; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Simplified Models

Simulation Environment: Network


Gansert J, Golowasch J, Nadim F. (2007). Sustained rhythmic activity in gap-junctionally coupled networks of model neurons depends on the diameter of coupled dendrites. Journal of neurophysiology. 98 [PubMed]

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