"... We have previously shown that the amplitude of electrical signals propagating across gap-junctionally coupled passive cables is maximized at a unique diameter. This suggests that threshold-dependent signals may propagate through gap junctions for a finite range of diameters around this optimal value. Here we examine the diameter dependence of action potential propagation across model networks of dendro-dendritically coupled neurons. The neurons in these models have passive soma and dendrites and an action potential-generating axon. We show that propagation of action potentials across gap junctions occurs only over a finite range of dendritic diameters and that propagation delay depends on this diameter. ...". See paper for more and details.
Model Type: Realistic Network; Neuron or other electrically excitable cell
Model Concept(s): Activity Patterns; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Simplified Models
Simulation Environment: Network
References:
Gansert J, Golowasch J, Nadim F. (2007). Sustained rhythmic activity in gap-junctionally coupled networks of model neurons depends on the diameter of coupled dendrites. Journal of neurophysiology. 98 [PubMed]