"... Our results suggest that a complex complement of ionic mechanisms is needed to fine-tune separate aspects of the neuronal response dynamics. Simulations also suggest that the Golgi cell may exploit these mechanisms to obtain a fine regulation of timing of incoming mossy fiber responses and granular layer circuit oscillation and bursting."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum golgi cell
Currents: I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I h
Genes: HCN1
Model Concept(s): Activity Patterns; Oscillations
Simulation Environment: NEURON; neuroConstruct (web link to model)
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it]; De Schutter, Erik [erik at oist.jp]
References:
Solinas S et al. (2007). Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Frontiers in cellular neuroscience. 1 [PubMed]
Solinas S et al. (2007). Fast-reset of pacemaking and theta-frequency resonance patterns in cerebellar golgi cells: simulations of their impact in vivo. Frontiers in cellular neuroscience. 1 [PubMed]