Efffect of propofol on potassium current in cardiac H9c2 cells (Liu et al. 2008)

"... The effects of propofol, an intravenous anesthetic agent with a distinct chemical structure, on ion currents of differentiated clonal cardiac (H9c2) cells were investigated in this study. Propofol ... suppressed the amplitude of delayed rectifier K(+) current (I(K(DR))) in a concentration-dependent manner with an IC(50) value of 36 muM. ... Propofol (30 muM) had no effect on erg-mediated K(+) current in these cells; however, it suppressed L-type Ca(2+) current (I(Ca,L)) of cardiac and skeletal types to a similar extent. ... Numerical simulations of I(K(DR)) based on a Markovian model reproduce the experimental results and show that propofol-induced blockade of I(K(DR)) is associated with an decrease in forward rate of the activation process and an increase in transitional rate into the inactivated state. ..."

Model Type: Channel/Receptor

Cell Type(s): Heart cell

Currents: I Potassium; I_Ks

Model Concept(s): Ion Channel Kinetics; Heart disease

Simulation Environment: XPPAUT


Liu YC, Wang YJ, Wu SN. (2008). The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. European journal of pharmacology. 590 [PubMed]

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