Model Concept: Ion Channel Kinetics

A model of ion channel kinetics derived from experimental data.

  1. A cardiac cell simulator (Puglisi and Bers 2001), applied to the QT interval (Busjahn et al 2004)
  2. A computational approach/model to explore NMDA receptors functions (Keller et al 2017)
  3. A dynamic model of the canine ventricular myocyte (Hund, Rudy 2004)
  4. A fast model of voltage-dependent NMDA Receptors (Moradi et al. 2013)
  5. A Markov model of human Cav2.3 channels and their modulation by Zn2+ (Neumaier et al 2020)
  6. A model for pituitary GH(3) lactotroph (Wu and Chang 2005)
  7. A model of ASIC1a and synaptic cleft pH modulating wind-up in wide dynamic range neurons (Delrocq)
  8. A model of beta-adrenergic modulation of IKs in the guinea-pig ventricle (Severi et al. 2009)
  9. A nicotinic acetylcholine receptor kinetic model (Edelstein et al. 1996)
  10. Accurate and fast simulation of channel noise in conductance-based model neurons (Linaro et al 2011)
  11. Action Potential initiation and backpropagation in Neocortical L5 Pyramidal Neuron (Hu et al. 2009)
  12. Action potential of mouse urinary bladder smooth muscle (Mahapatra et al 2018)
  13. Activity dependent changes in motoneurones (Dai Y et al 2002, Gardiner et al 2002)
  14. Activity dependent regulation of pacemaker channels by cAMP (Wang et al 2002)
  15. Alcohol action in a detailed Purkinje neuron model and an efficient simplified model (Forrest 2015)
  16. Allosteric gating of K channels (Horrigan et al 1999)
  17. An allosteric kinetics of NMDARs in STDP (Urakubo et al. 2008)
  18. Application of a common kinetic formalism for synaptic models (Destexhe et al 1994)
  19. Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)
  20. Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)
  21. BK - CaV coupling (Montefusco et al. 2017)
  22. Bursting and resonance in cerebellar granule cells (D'Angelo et al. 2001)
  23. Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
  24. Ca-dependent K Channel: kinetics from rat muscle (Moczydlowski, Latorre 1983) NEURON
  25. Ca-dependent K Channel: kinetics from rat muscle (Moczydlowski, Latorre 1983) XPP
  26. CA1 interneuron: K currents (Lien et al 2002)
  27. CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
  28. CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
  29. CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)
  30. CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
  31. CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
  32. CA1 pyramidal: Stochastic amplification of KCa in Ca2+ microdomains (Stanley et al. 2011)
  33. Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011)
  34. Calculating the consequences of left-shifted Nav channel activity in sick cells (Joos et al 2018)
  35. Cardiac action potential based on Luo-Rudy phase 1 model (Luo and Rudy 1991), (Wu 2004)
  36. Cardiac Atrial Cell (Courtemanche et al 1998)
  37. Cardiac Atrial Cell (Courtemanche et al 1998) (C++)
  38. Cerebellar Nucleus Neuron (Steuber, Schultheiss, Silver, De Schutter & Jaeger, 2010)
  39. Cerebellar purkinje cell: interacting Kv3 and Na currents influence firing (Akemann, Knopfel 2006)
  40. Cerebellar Purkinje Cell: resurgent Na current and high frequency firing (Khaliq et al 2003)
  41. Channel parameter estimation from current clamp and neuronal properties (Toth, Crunelli 2001)
  42. Chirp stimulus responses in a morphologically realistic model (Narayanan and Johnston, 2007)
  43. CN Octopus Cell: Ih current (Bal, Oertel 2000)
  44. Consequences of HERG mutations in the long QT syndrome (Clancy, Rudy 2001)
  45. Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)
  46. Dentate granule cell: mAHP & sAHP; SK & Kv7/M channels (Mateos-Aparicio et al., 2014)
  47. Dentate Gyrus Feed-forward inhibition (Ferrante et al. 2009)
  48. DG granule cell: I-A model (Beck et al 1992)
  49. Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs (vitale et al., 2023)
  50. Dopamine neuron of the vent. periaqu. gray and dors. raphe nucleus (vlPAG/DRN) (Dougalis et al 2017)
  51. Dorsal root ganglion (DRG) neuronal model (Kovalsky et al. 2009)
  52. DRG neuron models investigate how ion channel levels regulate firing properties (Zheng et al 2019)
  53. Effects of Dopamine Modulation and KIR Inactivation in NAc Medium Spiny Neurons (Steephen 2011)
  54. Effects of eugenol on the firing of action potentials in NG108-15 neurons (Huang et al. 2011)
  55. Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)
  56. Effects of neural morphology on global and focal NMDA-spikes (Poleg-Polsky 2015)
  57. Efffect of propofol on potassium current in cardiac H9c2 cells (Liu et al. 2008)
  58. Efficient Method for Computing Synaptic Conductance (Destexhe et al 1994)
  59. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)
  60. Enhancing the HH eqs: simulations based on the first publication in Biophys J (Moore 2015)
  61. ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007)
  62. Evaluation of stochastic diff. eq. approximation of ion channel gating models (Bruce 2009)
  63. Excitability of the soma in central nervous system neurons (Safronov et al 2000)
  64. Experimental and modeling studies of desensitization of P2X3 receptors (Sokolova et al. 2006)
  65. Febrile seizure-induced modifications to Ih (Chen et al 2001)
  66. FHF2KO and Wild-Type Mouse Cardiomyocyte Strands (Park et al 2020)
  67. FS Striatal interneuron: K currents solve signal-to-noise problems (Kotaleski et al 2006)
  68. Gap junction coupled network of striatal fast spiking interneurons (Hjorth et al. 2009)
  69. HH-type model of fast-spiking parvalbumin interneurons in spinal dorsal horn (Ma et al, 2023)
  70. Hippocampus CA1 pyramidal model with Na channel exhibiting slow inactivation (Menon et al. 2009)
  71. Hodgkin-Huxley model of persistent activity in PFC neurons (Winograd et al. 2008) (NEURON python)
  72. Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
  73. Hodgkin–Huxley model with fractional gating (Teka et al. 2016)
  74. Hysteresis in voltage gating of HCN channels (Elinder et al 2006, Mannikko et al 2005)
  75. I A in Kenyon cells resemble Shaker currents (Pelz et al 1999)
  76. Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment (Barlow et al., in press)
  77. INa and IKv4.3 heterogeneity in canine LV myocytes (Flaim et al 2006)
  78. Inhibition and glial-K+ interaction leads to diverse seizure transition modes (Ho & Truccolo 2016)
  79. Interneuron Specific 3 Interneuron Model (Guet-McCreight et al, 2016)
  80. Ion channel modeling with whole cell and a genetic algorithm (Gurkiewicz and Korngreen 2007)
  81. Ionic current model of a Hypoglossal Motoneuron (Purvis & Butera 2005)
  82. Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008)
  83. IP3R model comparison (Hituri and Linne 2013)
  84. Kinetic NMDA receptor model (Kampa et al 2004)
  85. Kinetic properties of voltage gated Na channel (Nayak and Sikdar 2007)
  86. Kinetic synaptic models applicable to building networks (Destexhe et al 1998)
  87. Kinetics of the P2X7 receptor as expressed in Xenopus oocytes (Riedel et al. 2007a,b)
  88. KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)
  89. Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000)
  90. Kv4.3, Kv1.4 encoded K(+) channel in heart cells (Greenstein et al 2000) (XPP)
  91. Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
  92. Low Threshold Calcium Currents in TC cells (Destexhe et al 1998) (Brian)
  93. Mammalian Ventricular Cell (Beeler and Reuter 1977)
  94. Markov Chain-based Stochastic Shielding Hodgkin Huxley Model (Schmandt, Galan 2012)
  95. Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004)
  96. Markovian model for cardiac sodium channel (Clancy, Rudy 2002)
  97. Markovian model for single-channel recordings of Ik_1 in ventricular cells (Matsuoka et al 2003)
  98. Maximal firing rate in midbrain dopamine neurons (Knowlton et al., 2021)
  99. Model for K-ATP mediated bursting in mSNc DA neurons (Knowlton et al 2018)
  100. Model of calcium oscillations in olfactory cilia (Reidl et al. 2006)
  101. Modeling interactions in Aplysia neuron R15 (Yu et al 2004)
  102. Models of Na channels from a paper on the PKC control of I Na,P (Baker 2005)
  103. ModFossa: a library for modeling ion channels using Python (Ferneyhough et al 2016)
  104. MyFirstNEURON (Houweling, Sejnowski 1997)
  105. Na channel mutations in the dentate gyrus (Thomas et al. 2009)
  106. Neocortical Layer I: I-A and I-K (Zhou, Hablitz 1996)
  107. Nerve terminal currents at lizard neuromuscular junction (Lindgren, Moore 1989)
  108. Neurophysiological impact of inactivation pathways in A-type K+ channels (Fineberg et al 2012)
  109. NMDA receptor saturation (Chen et al 2001)
  110. Novel Na current with slow de-inactivation (Tsutsui, Oka 2002)
  111. O-LM interneuron model (Lawrence et al. 2006)
  112. Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)
  113. Olfactory Mitral Cell: I-A and I-K currents (Wang et al 1996)
  114. Olfactory Periglomerular Cells: I-h kinetics (Cadetti, Belluzzi 2001)
  115. Olfactory receptor neuron model (Dougherty et al 2005)
  116. On stochastic diff. eq. models for ion channel noise in Hodgkin-Huxley neurons (Goldwyn et al. 2010)
  117. Pancreatic Beta Cell signalling pathways (Fridlyand & Philipson 2016) (MATLAB)
  118. Periodicity in Na channel properties alters model neuron excitability (Majumdar and Sikdar 2007)
  119. Permeation and inactivation of CaV1.2 Ca2+ channels (Babich et al. 2007)
  120. Properties of aconitine-induced block of KDR current in NG108-15 neurons (Lin et al. 2008)
  121. Pyramidal Neuron Deep: K+ kinetics (Korngreen, Sakmann 2000)
  122. Pyramidal neurons: IKHT offsets activation of IKLT to increase gain (Fernandez et al 2005)
  123. PyRhO: A multiscale optogenetics simulation platform (Evans et al 2016)
  124. Rapid desynchronization of an electrically coupled Golgi cell network (Vervaeke et al. 2010)
  125. Rat alpha7 nAChR desensitization is modulated by W55 (Gay et al. 2008)
  126. Rat phrenic motor neuron (Amini et al 2004)
  127. Reflected SDE Hodgkin-Huxley Model (Dangerfield et al. 2012)
  128. Regulation of KCNQ2/KCNQ3 current by G protein cycling (Suh et al 2004)
  129. Resonance properties through Chirp stimulus responses (Narayanan Johnston 2007, 2008)
  130. Retinal Ganglion Cell: I-A (Benison et al 2001)
  131. Retinal Ganglion Cell: I-CaN and I-CaL (Benison et al. 2001)
  132. Retinal Ganglion Cell: I-K (Skaliora et al 1995)
  133. Retinal Ganglion Cell: I-Na,t (Benison et al 2001)
  134. Retinal Photoreceptor: I Potassium (Beech, Barnes 1989)
  135. Rhesus Monkey Young and Aged L3 PFC Pyramidal Neurons (Rumbell et al. 2016)
  136. Rod photoreceptor (Barnes and Hille 1989, Publio et al. 2006, Kourennyi and Liu et al. 2004)
  137. Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005)
  138. Role of KCNQ1 and IKs in cardiac repolarization (Silva, Rudy 2005) (XPP)
  139. Salamander retinal ganglion cell: ion channels (Fohlmeister, Miller 1997)
  140. Simulating ion channel noise in an auditory brainstem neuron model (Schmerl & McDonnell 2013)
  141. Simulation study of Andersen-Tawil syndrome (Sung et al 2006)
  142. Sodium currents activate without a delay (Baranauskas and Martina 2006)
  143. Space clamp problems in neurons with voltage-gated conductances (Bar-Yehuda and Korngreen 2008)
  144. Spiking GridPlaceMap model (Pilly & Grossberg, PLoS One, 2013)
  145. Spinal Motor Neuron: Na, K_A, and K_DR currents (Safronov, Vogel 1995)
  146. Spontaneous firing caused by stochastic channel gating (Chow, White 1996)
  147. State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
  148. Stochastic automata network Markov model descriptors of coupled Ca2+ channels (Nguyen et al. 2005)
  149. Stochastic Ih and Na-channels in pyramidal neuron dendrites (Kole et al 2006)
  150. Stochastic model of the olfactory cilium transduction and adaptation (Antunes et al 2014)
  151. Stochastic versions of the Hodgkin-Huxley equations (Goldwyn, Shea-Brown 2011)
  152. Stochastic versions of the Hodgkin-Huxley equations (Goldwyn, Shea-Brown 2011) (pylab)
  153. Striatal Output Neuron (Mahon, Deniau, Charpier, Delord 2000)
  154. Subthreshold inact. of K channels modulates APs in bitufted interneurons (Korngreen et al 2005)
  155. Sympathetic Preganglionic Neurone (Briant et al. 2014)
  156. Synergistic inhibitory action of oxcarbazepine on INa and IK (Huang et al. 2008)
  157. T channel currents (Vitko et al 2005)
  158. T-type Ca current in thalamic neurons (Wang et al 1991)
  159. T-type Calcium currents (McRory et al 2001)
  160. Temporal decorrelation by intrinsic cellular dynamics (Wang et al 2003)
  161. Thalamic Relay Neuron: I-h (McCormick, Pape 1990)
  162. Thalamic Relay Neuron: I-T current (Williams, Stuart 2000)
  163. TTX-R Na+ current effect on cell response (Herzog et al 2001)
  164. TTX-R Na+ current effect on cell response (Herzog et al 2001) (MATLAB)
  165. Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++)
  166. Voltage and light-sensitive Channelrhodopsin-2 model (ChR2) (Williams et al. 2013)
  167. Voltage and light-sensitive Channelrhodopsin-2 model (ChR2-H134R) (Williams et al. 2013) (NEURON)
  168. VTA dopamine neuron (Tarfa, Evans, and Khaliq 2017)
  169. Zebrafish Mauthner-cell model (Watanabe et al 2017)
  170. Zonisamide-induced inhibition of the firing of APs in hippocampal neurons (Huang et al. 2007)
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