A computational approach/model to explore NMDA receptors functions (Keller et al 2017)

"... Here, we describe a general computational method aiming at developing kinetic Markov-chain based models of NMDARs subtypes capable of reproducing various experimental results. These models are then used to make predictions on additional (non-obvious) properties and on their role in synaptic function under various physiological and pharmacological conditions. For the purpose of this book chapter, we will focus on the method used to develop a NMDAR model that includes pharmacological site of action of different compounds. Notably, this elementary model can subsequently be included in a neuron model (not described in detail here) to explore the impact of their differential distribution on synaptic functions."

Model Type: Synapse

Receptors: NMDA

Model Concept(s): Ion Channel Kinetics


Keller AF, Bouteiller JC, Berger TW. (2017). Development of a Computational Approach/Model to Explore NMDA Receptors Functions. Methods in molecular biology (Clifton, N.J.). 1677 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.