...we constructed a simple, single-compartment model with Ih as the only active current... we found that both resonance frequency and resonance strength increased monotonically with the increase in the h conductance, supporting the notion of a direct, graded relationship between h conductance and resonance properties... (Narayanan and Johnston, 2007). ...we show that the h channels introduce an apparent negative delay in the local voltage response of these neurons with respect to the injected current within the theta frequency range... we found that the total inductive phase increased monotonically with the h conductance, whereas it had a bell-shaped dependence on both the membrane voltage and the half-maximal activation voltage for the h conductance. (Narayanan and Johnston, 2008).
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I h
Model Concept(s): Ion Channel Kinetics; Conductance distributions
Simulation Environment: NEURON
Implementer(s): Narayanan, Rishikesh [rishi at iisc.ac.in]
References:
Narayanan R, Johnston D. (2007). Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitability. Neuron. 56 [PubMed]
Narayanan R, Johnston D. (2008). The h channel mediates location dependence and plasticity of intrinsic phase response in rat hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]