Temporal decorrelation by intrinsic cellular dynamics (Wang et al 2003)

"... Recent investigations in primary visual (V1) cortical neurons have demonstrated that adaptation to prolonged changes in stimulus contrast is mediated in part through intrinsic ionic currents, a Ca2+ activated K+ current (IKCa) and especially a Na+ activated K+ current (IKNa). The present study was designed to test the hypothesis that the activation of adaptation ionic currents may provide a cellular mechanism for temporal decorrelation in V1. A conductance-based neuron model was simulated, which included an IKCa and an IKNa. We show that the model neuron reproduces the adaptive behavior of V1 neurons in response to high contrast inputs. ...". See paper for details and more.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L2/3 pyramidal GLU cell

Currents: I Na,t; I L high threshold; I K; I Calcium; I Potassium

Model Concept(s): Ion Channel Kinetics; Temporal Pattern Generation; Oscillations; Calcium dynamics; Vision

Simulation Environment: C or C++ program

Implementer(s): Wang, Xiao-Jing [xjwang at yale.edu]


Wang XJ, Liu Y, Sanchez-Vives MV, McCormick DA. (2003). Adaptation and temporal decorrelation by single neurons in the primary visual cortex. Journal of neurophysiology. 89 [PubMed]

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