Current: I L high threshold

"Long-lasting"; slowly inactivating; threshold around -20 mV

  1. A 1000 cell network model for Lateral Amygdala (Kim et al. 2013)
  2. A focal seizure model with ion concentration changes (Gentiletti et al., 2022)
  3. A multi-compartment model for interneurons in the dLGN (Halnes et al. 2011)
  4. A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)
  5. A network model of tail withdrawal in Aplysia (White et al 1993)
  6. A single column thalamocortical network model (Traub et al 2005)
  7. A synapse model for developing somatosensory cortex (Manninen et al 2020)
  8. A two-layer biophysical olfactory bulb model of cholinergic neuromodulation (Li and Cleland 2013)
  9. A unified thalamic model of multiple distinct oscillations (Li, Henriquez and Fröhlich 2017)
  10. Action potential of mouse urinary bladder smooth muscle (Mahapatra et al 2018)
  11. Activity dependent changes in motoneurones (Dai Y et al 2002, Gardiner et al 2002)
  12. Activity dependent conductances in a neuron model (Liu et al. 1998)
  13. Afferent Integration in the NAcb MSP Cell (Wolf et al. 2005)
  14. Allen Institute: Gad2-IRES-Cre VISp layer 5 472447460
  15. Allen Institute: Gad2-IRES-Cre VISp layer 5 473561729
  16. Allen Institute: Htr3a-Cre VISp layer 2/3 472352327
  17. Allen Institute: Htr3a-Cre VISp layer 2/3 472421285
  18. Allen Institute: Nr5a1-Cre VISp layer 2/3 473862496
  19. Allen Institute: Nr5a1-Cre VISp layer 4 329322394
  20. Allen Institute: Nr5a1-Cre VISp layer 4 472306544
  21. Allen Institute: Nr5a1-Cre VISp layer 4 472442377
  22. Allen Institute: Nr5a1-Cre VISp layer 4 472451419
  23. Allen Institute: Nr5a1-Cre VISp layer 4 472915634
  24. Allen Institute: Nr5a1-Cre VISp layer 4 473834758
  25. Allen Institute: Nr5a1-Cre VISp layer 4 473863035
  26. Allen Institute: Nr5a1-Cre VISp layer 4 473871429
  27. Allen Institute: Ntsr1-Cre VISp layer 4 472430904
  28. Allen Institute: Pvalb-IRES-Cre VISp layer 2/3 472306616
  29. Allen Institute: Pvalb-IRES-Cre VISp layer 5 471085845
  30. Allen Institute: Pvalb-IRES-Cre VISp layer 5 472349114
  31. Allen Institute: Pvalb-IRES-Cre VISp layer 5 472912177
  32. Allen Institute: Pvalb-IRES-Cre VISp layer 5 473465774
  33. Allen Institute: Pvalb-IRES-Cre VISp layer 5 473862421
  34. Allen Institute: Pvalb-IRES-Cre VISp layer 6a 471081668
  35. Allen Institute: Pvalb-IRES-Cre VISp layer 6a 472301074
  36. Allen Institute: Pvalb-IRES-Cre VISp layer 6a 473860269
  37. Allen Institute: Rbp4-Cre VISp layer 5 472424854
  38. Allen Institute: Rbp4-Cre VISp layer 6a 473871592
  39. Allen Institute: Rorb-IRES2-Cre-D VISp layer 2/3 472299294
  40. Allen Institute: Rorb-IRES2-Cre-D VISp layer 2/3 472434498
  41. Allen Institute: Rorb-IRES2-Cre-D VISp layer 4 473863510
  42. Allen Institute: Rorb-IRES2-Cre-D VISp layer 5 471087975
  43. Allen Institute: Rorb-IRES2-Cre-D VISp layer 5 473561660
  44. Allen Institute: Scnn1a-Tg2-Cre VISp layer 4 472300877
  45. Allen Institute: Scnn1a-Tg2-Cre VISp layer 4 472427533
  46. Allen Institute: Scnn1a-Tg2-Cre VISp layer 4 472912107
  47. Allen Institute: Scnn1a-Tg2-Cre VISp layer 4 473465456
  48. Allen Institute: Scnn1a-Tg2-Cre VISp layer 5 472306460
  49. Allen Institute: Scnn1a-Tg3-Cre VISp layer 4 329321704
  50. Allen Institute: Scnn1a-Tg3-Cre VISp layer 4 472363762
  51. Allen Institute: Scnn1a-Tg3-Cre VISp layer 4 473862845
  52. Allen Institute: Scnn1a-Tg3-Cre VISp layer 4 473872986
  53. Allen Institute: Scnn1a-Tg3-Cre VISp layer 5 472455509
  54. Allen Institute: Scnn1a-Tg3-Cre VISp layer 5 473863578
  55. Allen Institute: Scnn1a-Tg3-Cre VISp layer 5 473871773
  56. Allen Institute: Sst-IRES-Cre VISp layer 2/3 471086533
  57. Allen Institute: Sst-IRES-Cre VISp layer 2/3 472304676
  58. Allen Institute: Sst-IRES-Cre VISp layer 4 472304539
  59. Allen Institute: Sst-IRES-Cre VISp layer 5 472299363
  60. Allen Institute: Sst-IRES-Cre VISp layer 5 472450023
  61. Allen Institute: Sst-IRES-Cre VISp layer 5 473835796
  62. Allen Institute: Sst-IRES-Cre VISp layer 6a 472440759
  63. Alpha rhythm in vitro visual cortex (Traub et al 2020)
  64. Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
  65. AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
  66. Apical Length Governs Computational Diversity of Layer 5 Pyramidal Neurons (Galloni et al 2020)
  67. Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)
  68. Axonal Projection and Interneuron Types (Helmstaedter et al. 2008)
  69. Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)
  70. CA1 pyramidal neuron (Combe et al 2018)
  71. CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
  72. CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
  73. CA1 pyramidal neuron: synaptically-induced bAP predicts synapse location (Sterratt et al. 2012)
  74. CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994)
  75. CA3 pyramidal neuron (Lazarewicz et al 2002)
  76. CA3 Pyramidal Neuron (Migliore et al 1995)
  77. CA3 pyramidal neuron (Safiulina et al. 2010)
  78. CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
  79. Calcium and potassium currents of olfactory bulb juxtaglomerular cells (Masurkar and Chen 2011)
  80. Calcium influx during striatal upstates (Evans et al. 2013)
  81. Calcium response prediction in the striatal spines depending on input timing (Nakano et al. 2013)
  82. Calcium spikes in basal dendrites (Kampa and Stuart 2006)
  83. Calcium waves and mGluR-dependent synaptic plasticity in CA1 pyr. neurons (Ashhad & Narayanan 2013)
  84. Cardiac Atrial Cell (Courtemanche et al 1998)
  85. Cardiac Atrial Cell (Courtemanche et al 1998) (C++)
  86. Cell signaling/ion channel variability effects on neuronal response (Anderson, Makadia, et al. 2015)
  87. Cerebellar granular layer (Maex and De Schutter 1998)
  88. Changes of ionic concentrations during seizure transitions (Gentiletti et al. 2016)
  89. Channel density variability among CA1 neurons (Migliore et al. 2018)
  90. CN bushy, stellate neurons (Rothman, Manis 2003)
  91. CN bushy, stellate neurons (Rothman, Manis 2003) (Brian 2)
  92. CN bushy, stellate neurons (Rothman, Manis 2003) (Brian)
  93. Collection of simulated data from a thalamocortical network model (Glabska, Chintaluri, Wojcik 2017)
  94. Compartmentalization of GABAergic inhibition by dendritic spines (Chiu et al. 2013)
  95. Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)
  96. Computational model of bladder small DRG neuron soma (Mandge & Manchanda 2018)
  97. Computational modeling of ultrasonic Subthalamic Nucleus stimulation (Tarnaud et al 2019)
  98. Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
  99. Conductance-based model of rodent thoracic sympathetic postganglionic neuron (McKinnon et al 2019)
  100. Cortex-Basal Ganglia-Thalamus network model (Kumaravelu et al. 2016)
  101. Cortical Basal Ganglia Network Model during Closed-loop DBS (Fleming et al 2020)
  102. Deconstruction of cortical evoked potentials generated by subthalamic DBS (Kumaravelu et al 2018)
  103. Decorrelation in the developing visual thalamus (Tikidji-Hamburyan et al, accepted)
  104. Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)
  105. Dendritic processing of excitatory synaptic input in GnRH neurons (Roberts et al. 2006)
  106. Dendritica (Vetter et al 2001)
  107. Dentate granule cell: mAHP & sAHP; SK & Kv7/M channels (Mateos-Aparicio et al., 2014)
  108. Dentate gyrus granule cell: calcium and calcium-dependent conductances (Aradi and Holmes 1999)
  109. Dentate gyrus network model (Santhakumar et al 2005)
  110. Dentate gyrus network model (Tejada et al 2014)
  111. Determinants of the intracellular and extracellular waveforms in DA neurons (Lopez-Jury et al 2018)
  112. Differential modulation of pattern and rate in a dopamine neuron model (Canavier and Landry 2006)
  113. Discharge hysteresis in motoneurons (Powers & Heckman 2015)
  114. Discrimination on behavioral time-scales mediated by reaction-diffusion in dendrites (Bhalla 2017)
  115. Double cable myelinated axon (Layer 5 pyramidal neuron; Cohen et al 2020)
  116. Dynamic cortical interlaminar interactions (Carracedo et al. 2013)
  117. Dynamical assessment of ion channels during in vivo-like states (Guet-McCreight & Skinner 2020)
  118. Dynamical model of olfactory bulb mitral cell (Rubin, Cleland 2006)
  119. Effects of Acetyl-L-carnitine on neural transmission (Lombardo et al 2004)
  120. Effects of Dopamine Modulation and KIR Inactivation in NAc Medium Spiny Neurons (Steephen 2011)
  121. Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)
  122. Electrodecrements in in vitro model of infantile spasms (Traub et al 2020)
  123. Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)
  124. Enhanced Excitability in Hermissenda: modulation by 5-HT (Cai et al 2003)
  125. ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007)
  126. Excitability of PFC Basal Dendrites (Acker and Antic 2009)
  127. Excitation-contraction coupling in an integrative heart cell model (Greenstein et al 2006)
  128. Excitation-contraction coupling/mitochondrial energetics (ECME) model (Cortassa et al. 2006)
  129. Fast oscillations in inhibitory networks (Maex, De Schutter 2003)
  130. FHF2KO and Wild-Type Mouse Cardiomyocyte Strands (Park et al 2020)
  131. Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)
  132. Gamma genesis in the basolateral amygdala (Feng et al 2019)
  133. Global structure, robustness, and modulation of neuronal models (Goldman et al. 2001)
  134. Globus pallidus multi-compartmental model neuron with realistic morphology (Gunay et al. 2008)
  135. Hodgkin-Huxley model of persistent activity in PFC neurons (Winograd et al. 2008) (NEURON python)
  136. Hodgkin-Huxley model of persistent activity in prefrontal cortex neurons (Winograd et al. 2008)
  137. Hodgkin-Huxley models of different classes of cortical neurons (Pospischil et al. 2008)
  138. Hyperexcitability from Nav1.2 channel loss in neocortical pyramidal cells (Spratt et al 2021)
  139. Hysteresis in voltage gating of HCN channels (Elinder et al 2006, Mannikko et al 2005)
  140. Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)
  141. Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
  142. Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)
  143. Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)
  144. Ionic current model of a Hypoglossal Motoneuron (Purvis & Butera 2005)
  145. Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008)
  146. Irregular spiking in NMDA-driven prefrontal cortex neurons (Durstewitz and Gabriel 2006)
  147. Ketamine disrupts theta modulation of gamma in a computer model of hippocampus (Neymotin et al 2011)
  148. KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)
  149. Kv4.3, Kv1.4 encoded K channel in heart cells & tachy. (Winslow et al 1999, Greenstein et al 2000)
  150. L2/3 V1 Pyramidal Cell model (modified Park et al., 2019; a/n: 231185) (Petousakis et al., 2023)
  151. L5 PFC microcircuit used to study persistent activity (Papoutsi et al. 2014, 2013)
  152. L5 PFC pyramidal neurons (Papoutsi et al. 2017)
  153. L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
  154. Lateral dendrodenditic inhibition in the Olfactory Bulb (David et al. 2008)
  155. Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
  156. Layer V pyramidal cell functions and schizophrenia genetics (Mäki-Marttunen et al 2019)
  157. Layer V pyramidal cell model with reduced morphology (Mäki-Marttunen et al 2018)
  158. LCN-HippoModel: model of CA1 PCs deep-superficial theta firing dynamics (Navas-Olive et al 2020)
  159. Leech S Cell: Modulation of Excitability by Serotonin (Burrell and Crisp 2008)
  160. Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)
  161. Long-Term Inactivation of Na+ Channels as a Mech of Adaptation in CA1 Pyr Cells (Upchurch et al '22)
  162. Mathematical model for windup (Aguiar et al. 2010)
  163. Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)
  164. Medial vestibular neuron models (Quadroni and Knopfel 1994)
  165. Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
  166. Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)
  167. Multitarget pharmacology for Dystonia in M1 (Neymotin et al 2016)
  168. MyFirstNEURON (Houweling, Sejnowski 1997)
  169. Neocortical pyramidal neuron: deep; effects of dopamine (Durstewitz et al 2000)
  170. Network model of the granular layer of the cerebellar cortex (Maex, De Schutter 1998)
  171. NMDA subunit effects on Calcium and STDP (Evans et al. 2012)
  172. O-LM interneuron model (Lawrence et al. 2006)
  173. Olfactory bulb mitral cell gap junction NN model: burst firing and synchrony (O`Connor et al. 2012)
  174. Olfactory Bulb Network (Davison et al 2003)
  175. Olfactory Mitral Cell (Bhalla, Bower 1993)
  176. Olfactory Mitral Cell (Davison et al 2000)
  177. Orientation preference in L23 V1 pyramidal neurons (Park et al 2019)
  178. Paradoxical GABA-mediated excitation (Lewin et al. 2012)
  179. Parameter estimation for Hodgkin-Huxley based models of cortical neurons (Lepora et al. 2011)
  180. Permeation and inactivation of CaV1.2 Ca2+ channels (Babich et al. 2007)
  181. Phase plane reveals two slow variables in midbrain dopamine neuron bursts (Yu and Canavier, 2015)
  182. Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)
  183. Preserving axosomatic spiking features despite diverse dendritic morphology (Hay et al., 2013)
  184. Pyramidal Neuron Deep: Constrained by experiment (Dyhrfjeld-Johnsen et al. 2005)
  185. Pyramidal neuron, fast, regular, and irregular spiking interneurons (Konstantoudaki et al 2014)
  186. Rapid desynchronization of an electrically coupled Golgi cell network (Vervaeke et al. 2010)
  187. Rat phrenic motor neuron (Amini et al 2004)
  188. Rat subthalamic projection neuron (Gillies and Willshaw 2006)
  189. Reduced-morphology model of CA1 pyramidal cells optimized + validated w/ HippoUnit (Tomko et al '21)
  190. Regulation of firing frequency in a midbrain dopaminergic neuron model (Kuznetsova et al. 2010)
  191. Relating anatomical and biophysical properties to motoneuron excitabilty (Moustafa et al. 2023)
  192. Retinal Ganglion Cell: I-CaN and I-CaL (Benison et al. 2001)
  193. Ribbon Synapse (Sikora et al 2005)
  194. Robust and tunable bursting requires slow positive feedback (Franci et al 2018)
  195. Robust transmission in the inhibitory Purkinje Cell to Cerebellar Nuclei pathway (Abbasi et al 2017)
  196. Role of afferent-hair cell connectivity in determining spike train regularity (Holmes et al 2017)
  197. Role of the AIS in the control of spontaneous frequency of dopaminergic neurons (Meza et al 2017)
  198. Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
  199. SCZ-associated variant effects on L5 pyr cell NN activity and delta osc. (Maki-Marttunen et al 2018)
  200. Self-organized olfactory pattern recognition (Kaplan & Lansner 2014)
  201. Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
  202. Simulated light response in rod photoreceptors (Liu and Kourennyi 2004)
  203. Simulation study of Andersen-Tawil syndrome (Sung et al 2006)
  204. Sleep-wake transitions in corticothalamic system (Bazhenov et al 2002)
  205. Specific inhibition of dendritic plateau potential in striatal projection neurons (Du et al 2017)
  206. Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation (Luque et al 2019)
  207. Spinal motoneuron recruitment regulated by ionic channels during fictive locomotion (Zhang & Dai 20)
  208. Spiny Projection Neuron Ca2+ based plasticity is robust to in vivo spike train (Dorman&Blackwell)
  209. STD-dependent and independent encoding of Input irregularity as spike rate (Luthman et al. 2011)
  210. STDP depends on dendritic synapse location (Letzkus et al. 2006)
  211. Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
  212. Study of augmented Rubin and Terman 2004 deep brain stim. model in Parkinsons (Pascual et al. 2006)
  213. Sympathetic Preganglionic Neurone (Briant et al. 2014)
  214. Synaptic integration in a model of granule cells (Gabbiani et al 1994)
  215. Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)
  216. Systematic integration of data into multi-scale models of mouse primary V1 (Billeh et al 2020)
  217. Temporal decorrelation by intrinsic cellular dynamics (Wang et al 2003)
  218. Thalamic interneuron multicompartment model (Zhu et al. 1999)
  219. Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)
  220. Thalamocortical Relay cell under current clamp in high-conductance state (Zeldenrust et al 2018)
  221. Thalamocortical relay neuron models constrained by experiment and optimization (Iavarone et al 2019)
  222. The APP in C-terminal domain alters CA1 neuron firing (Pousinha et al 2019)
  223. The origin of different spike and wave-like events (Hall et al 2017)
  224. The subcellular distribution of T-type Ca2+ channels in LGN interneurons (Allken et al. 2014)
  225. Theta phase precession in a model CA3 place cell (Baker and Olds 2007)
  226. Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit (Ponzi et al. 2023)
  227. Touch Sensory Cells (T Cells) of the Leech (Cataldo et al. 2004) (Scuri et al. 2007)
  228. Turtle visual cortex model (Nenadic et al. 2003, Wang et al. 2005, Wang et al. 2006)
  229. Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
  230. Ventricular cell model (Guinea-pig-type) (Luo, Rudy 1991, +11 other papers!) (C++)
  231. Ventromedial Thalamocortical Neuron (Bichler et al 2021)
  232. Visual physiology of the layer 4 cortical circuit in silico (Arkhipov et al 2018)
  233. VTA dopamine neuron (Tarfa, Evans, and Khaliq 2017)
Top authors for I L high threshold:
Top concepts studied with I L high threshold:
Top neurons studied with I L high threshold:
Top currents studied with I L high threshold:
Top references cited by these models:
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.