The authors present data and a kinetics model of the CaV1.2 channel supporting the idea that Ca2+ block of the pore generates the U-shaped inactivation curve.
Model Type: Channel/Receptor
Currents: I L high threshold
Model Concept(s): Ion Channel Kinetics
Simulation Environment: CalC Calcium Calculator (web link to model)
Babich O, Matveev V, Harris AL, Shirokov R. (2007). Ca2+-dependent inactivation of CaV1.2 channels prevents Gd3+ block: does Ca2+ block the pore of inactivated channels? The Journal of general physiology. 129 [PubMed]