Permeation and inactivation of CaV1.2 Ca2+ channels (Babich et al. 2007)

The authors present data and a kinetics model of the CaV1.2 channel supporting the idea that Ca2+ block of the pore generates the U-shaped inactivation curve.

Model Type: Channel/Receptor

Currents: I L high threshold

Model Concept(s): Ion Channel Kinetics

Simulation Environment: CalC Calcium Calculator (web link to model)


Babich O, Matveev V, Harris AL, Shirokov R. (2007). Ca2+-dependent inactivation of CaV1.2 channels prevents Gd3+ block: does Ca2+ block the pore of inactivated channels? The Journal of general physiology. 129 [PubMed]

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