Using a data-driven model of a hippocampal microcircuit, we demonstrate that theta-gamma phase amplitude coupling (PAC) can naturally emerge from a single feedback mechanism involving an inhibitory and excitatory neuron population, which interplay to generate theta frequency periodic bursts of higher frequency gamma..
Model Type: Realistic Network
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Hippocampus CA1 stratum oriens lacunosum-moleculare interneuron ; Hippocampus CA1 basket cell
Currents: I h; I K,Ca; I K; I Calcium; I CAN; I M; I Na,t; Ca pump; I A; I T low threshold; I L high threshold; I_KD
Model Concept(s): Oscillations; Gamma oscillations; Theta oscillations
Simulation Environment: NetPyNE
References:
Ponzi A, Dura-Bernal S, Migliore M. (2023). Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit PLoS Computational Biology.