Using a data-driven model of a hippocampal microcircuit, we demonstrate that theta-gamma phase amplitude coupling (PAC) can naturally emerge from a single feedback mechanism involving an inhibitory and excitatory neuron population, which interplay to generate theta frequency periodic bursts of higher frequency gamma..
Model Type: Realistic Network
Region(s) or Organism(s): Hippocampus
Simulation Environment: NetPyNE
Ponzi A, Dura-Bernal S, Migliore M. (2023). Theta-gamma phase amplitude coupling in a hippocampal CA1 microcircuit PLoS Computational Biology.