A biologically-detailed model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. For more details, see the reference below.
Model Type: Realistic Network
Region(s) or Organism(s): Olfactory bulb
Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell
Currents: I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium
Model Concept(s): Oscillations; Synchronization; Spatio-temporal Activity Patterns; Olfaction
Simulation Environment: NEURON
Implementer(s): Davison, Andrew [Andrew.Davison at iaf.cnrs-gif.fr]
References:
Davison AP, Feng J, Brown D. (2003). Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. Journal of neurophysiology. 90 [PubMed]