We developed a model for an L4-L2/3 synapse in somatosensory cortex to study the role of astrocytes in modulation of t-LTD. Our model includes the one-compartmental presynaptic L4 spiny stellate cell, two-compartmental (soma and dendrite) postsynaptic L2/3 pyramidal cell, and one-compartmental fine astrocyte process.
Region(s) or Organism(s): Barrel cortex
Cell Type(s): Neocortex L2/3 pyramidal GLU cell; Astrocyte; Neocortex spiny stellate cell
Currents: Ca pump; I CAN; I Na,p; I_SERCA; I_KD; I A; I K; I N; I L high threshold; I C
Receptors: NMDA; AMPA; IP3; mGluR
Transmitters: Glutamate; Endocannabinoid
Model Concept(s): Development; Long-term Synaptic Plasticity; Synaptic Plasticity; Calcium dynamics; STDP
Simulation Environment: Python
Implementer(s): Manninen, Tiina [tiina.h.manninen at gmail.com]; Saudargiene, Ausra [ausra.saudargiene at gmail.com]
References:
Manninen T, Saudargiene A, Linne ML. (2020). Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS computational biology. 16 [PubMed]