In a network of 6 mitral cells connected by gap junction in the apical dendrite tuft, continuous current injections of 0.06 nA are injected into 20 locations in the apical tufts of two of the mitral cells. The current injections into one of the cells starts 10 ms after the other to generate asynchronous firing in the cells (Migliore et al. 2005 protocol). Firing of the cells is asynchronous for the first 120 ms. However after the burst firing phase is completed the firing in all cells becomes synchronous.
Model Type: Realistic Network
Region(s) or Organism(s): Olfactory bulb
Cell Type(s): Olfactory bulb main mitral GLU cell
Currents: I Na,t; I L high threshold; I A; I K; I K,Ca
Model Concept(s): Bursting; Oscillations; Synchronization; Active Dendrites; Influence of Dendritic Geometry; Calcium dynamics; Olfaction
Simulation Environment: NEURON
References:
O'Connor S, Angelo K, Jacob TJ. (2012). Burst firing versus synchrony in a gap junction connected olfactory bulb mitral cell network model Frontiers in computational neuroscience. 6 [PubMed]