"We have developed a single-compartment, electrophysiological, hypoglossal motoneuron (HM) model based primarily on experimental data from neonatal rat HMs. The model is able to reproduce the fine features of the HM action potential: the fast afterhyperpolarization, the afterdepolarization, and the medium-duration afterhyperpolarization (mAHP). The model also reproduces the repetitive firing properties seen in neonatal HMs and replicates the neuron’s response to pharmacological experiments. The model was used to study the role of specific ionic currents in HM firing and how variations in the densities of these currents may account for age dependent changes in excitability seen in HMs. ..."
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Hypoglossal motor neuron
Currents: I Calcium; I Potassium; I h; I L high threshold; I T low threshold; I K,Ca; I Na,t
Model Concept(s): Action Potentials; Calcium dynamics; Ion Channel Kinetics; Activity Patterns; Simplified Models
Simulation Environment: CellML (web link to model)
References:
Purvis LK, Butera RJ. (2005). Ionic current model of a hypoglossal motoneuron. Journal of neurophysiology. 93 [PubMed]