CA3 pyramidal neuron: firing properties (Hemond et al. 2008)

In the paper, this model was used to identify how relative differences in K+ conductances, specifically KC, KM, & KD, between cells contribute to the different characteristics of the three types of firing patterns observed experimentally.

Model Type: Dendrite

Cell Type(s): Hippocampus CA3 pyramidal GLU cell

Currents: I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I Potassium

Model Concept(s): Bursting; Active Dendrites; Detailed Neuronal Models; Action Potentials

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]

References:

Hemond P et al. (2008). Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b. Hippocampus. 18 [PubMed]