"... We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS of cortical neurons. ... In combination with simulations using a realistic computer model of a CA1 pyramidal cell, our results imply that a hyperpolarized voltage-dependence of activation of AIS NaV1.6 channels is important both in determining spike threshold and localizing spike initiation to the AIS. ... These results suggest that NaV1.6 subunits at the AIS contribute significantly to its role as spike trigger zone and shape repetitive discharge properties of CA1 neurons."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I M; I h; I K,Ca; I Calcium; I Q
Genes: Nav1.6 SCN8A
Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Temporal Pattern Generation
Simulation Environment: NEURON
Implementer(s): Horstmann, Marie-Therese [mhorstma at uni-bonn.de]
References:
Royeck M et al. (2008). Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology. 100 [PubMed]