This simple axon-soma model explained how the rapid rising phase in the somatic spike is derived from the propagated axon initiated spike, and how the somatic spike threshold variance is affected by spike propagation.
Model Type: Neuron or other electrically excitable cell; Axon
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell
Currents: I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP
Model Concept(s): Action Potential Initiation; Detailed Neuronal Models
Simulation Environment: NEURON
References:
McCormick DA, Shu Y, Yu Y. (2007). Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445 [PubMed]
Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]