" ... We evaluated the impact of molecular variability in the expression of cell signaling components and ion channels on electrophysiological excitability and neuromodulation. We employed a computational approach that integrated neuropeptide receptor-mediated signaling with electrophysiology. We simulated a population of neurons in which expression levels of a neuropeptide receptor and multiple ion channels were simultaneously varied within a physiological range. We analyzed the effects of variation on the electrophysiological response to a neuropeptide stimulus. ..."
Cell Type(s): Brainstem neuron
Model Concept(s): Activity Patterns; Action Potentials; Signaling pathways; Spike Frequency Adaptation; Parameter sensitivity; Depolarization block; G-protein coupled; Conductance distributions; Bifurcation; Synaptic noise; Neuromodulation
Simulation Environment: MATLAB