Visual physiology of the layer 4 cortical circuit in silico (Arkhipov et al 2018)

"Despite advances in experimental techniques and accumulation of large datasets concerning the composition and properties of the cortex, quantitative modeling of cortical circuits under in-vivo-like conditions remains challenging. Here we report and publicly release a biophysically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo- cortical visual inputs. The 45,000-neuron model was subjected to a battery of visual stimuli, and results were compared to published work and new in vivo experiments. ..."

Model Type: Realistic Network; Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex V1 interneuron chandelier SOM GABA cell; Neocortex V1 interneuron basket PV GABA cell; Neocortex layer 4 pyramidal cell

Currents: I L high threshold; I T low threshold; I M; I Krp; I K; I Na,p; I Na,t; IK Skca

Model Concept(s): Simplified Models; Detailed Neuronal Models; Brain Rhythms; Gamma oscillations; Triggered activity; Activity Patterns; Orientation selectivity

Simulation Environment: NEURON (web link to model); BioNet (web link to model)


Arkhipov A et al. (2018). Visual physiology of the layer 4 cortical circuit in silico. PLoS computational biology. 14 [PubMed]

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