"Cerebellar Purkinje cells mediate accurate eye movement coordination. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. ..."
Model Type: Neuron or other electrically excitable cell; Realistic Network
Region(s) or Organism(s): Cerebellum
Cell Type(s): Cerebellum Purkinje GABA cell; Cerebellum interneuron granule GLU cell; Vestibular neuron; Abstract integrate-and-fire leaky neuron
Currents: I K; I Na,t; I L high threshold; I M
Model Concept(s): Activity Patterns; Sleep; Long-term Synaptic Plasticity; Vestibular
Simulation Environment: EDLUT; NEURON; MATLAB
Implementer(s): Luque, Niceto R. [nluque at ugr.es]
References:
Luque NR, Naveros F, Carrillo RR, Ros E, Arleo A. (2019). Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS computational biology. 15 [PubMed]