Neocortical Layer V model with firing behaviour adjusted to in vitro observations. The model was used to investigate the effects of IFN and PKC on the excitability of neurons (Stadler et al 2014, Reetz et al. 2014). The model contains new channel simulations for HCN1, HCN2 and the big calcium dependent potassium channel BK.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Neocortex
Cell Type(s): Neocortex L5/6 pyramidal GLU cell
Simulation Environment: NEURON
Implementer(s): Stadler, Konstantin [konstantin.stadler at ntnu.no]
Reetz O, Stadler K, Strauss U. (2014). Protein kinase C activation mediates interferon-ß-induced neuronal excitability changes in neocortical pyramidal neurons. Journal of neuroinflammation. 11 [PubMed]