A computational model of the rat subthalamic nucleus projection neuron is constructed using electrophysiological and morphological data and a restricted set of channel specifications. The model cell exhibits a wide range of electrophysiological behaviors characteristic of rat subthalamic neurons. It reveals that a key set of three channels play a primary role in distinguishing behaviors: a high-voltage-activated calcium channel (Cav 1.2.-1.3), a low-voltage-activated calcium channel (Cav 3.-), and a small current calcium-activated potassium channel (KCa 2.1-2.3). See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Subthalamus nucleus projection neuron
Model Concept(s): Bursting
Simulation Environment: NEURON
Implementer(s): Gillies, Andrew [andrew at anc.ed.ac.uk]