Rat subthalamic projection neuron (Gillies and Willshaw 2006)

A computational model of the rat subthalamic nucleus projection neuron is constructed using electrophysiological and morphological data and a restricted set of channel specifications. The model cell exhibits a wide range of electrophysiological behaviors characteristic of rat subthalamic neurons. It reveals that a key set of three channels play a primary role in distinguishing behaviors: a high-voltage-activated calcium channel (Cav 1.2.-1.3), a low-voltage-activated calcium channel (Cav 3.-), and a small current calcium-activated potassium channel (KCa 2.1-2.3). See paper for more and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Subthalamus nucleus projection neuron

Currents: I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I K; I h; I K,Ca; I Calcium; I Mixed

Genes: Cav1.3 CACNA1D; Cav1.2 CACNA1C; KCa2.1 KCNN1; Kv2.1 KCNB1; Kv3.1 KCNC1; HCN Cnga1; Cav2.2 CACNA1B; KCa2.2 KCNN2

Model Concept(s): Bursting

Simulation Environment: NEURON

Implementer(s): Gillies, Andrew [andrew at anc.ed.ac.uk]


Gillies A, Willshaw D. (2006). Membrane channel interactions underlying rat subthalamic projection neuron rhythmic and bursting activity. Journal of neurophysiology. 95 [PubMed]

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