Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)

From Zhu and Clancy: "... Here we employ theoretical simulations to examine the effects of a Timothy Syndrome (TS) mutation in the L-type Ca2+ channel on cardiac dynamics over multiple scales, from a gene mutation to protein, cell, tissue, and finally the ECG, to connect a defective Ca2+ channel to arrhythmia susceptibility. ..."

Model Type: Neuron or other electrically excitable cell; Electrogenic pump

Currents: I Na,t; I L high threshold; I Calcium; I Potassium; Na/Ca exchanger; I_Ks; Na/K pump

Model Concept(s): Temporal Pattern Generation; Heart disease; Long-QT; Timothy Syndrome; Sodium pump

Simulation Environment: C or C++ program

Implementer(s): Zhu, Zheng I. [zhz2001 at]


Fox JJ, McHarg JL, Gilmour RF. (2002). Ionic mechanism of electrical alternans. American journal of physiology. Heart and circulatory physiology. 282 [PubMed]

Zhu ZI, Clancy CE. (2007). L-type Ca2+ channel mutations and T-wave alternans: a model study. American journal of physiology. Heart and circulatory physiology. 293 [PubMed]

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