"Objective: To explore the potential of ultrasonic modulation of plateau-potential generating subthalamic nucleus neurons (STN), by modeling their interaction with continuous and pulsed ultrasonic waves. Methods: A computational model for ultrasonic stimulation of the STN is created by combining the Otsuka-model with the bilayer sonophore model. The neuronal response to continuous and pulsed ultrasonic waves is computed in parallel for a range of frequencies, duty cycles, pulse repetition frequencies, and intensities. ..."
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia; Subthalamic Nucleus
Cell Type(s): Subthalamus nucleus projection neuron
Currents: I Na,t; I A; I K; I K,Ca; I T low threshold; I L high threshold
Model Concept(s): Parkinson's; Deep brain stimulation; Activity Patterns
Simulation Environment: MATLAB
Implementer(s): Tarnaud, Thomas [Thomas.Tarnaud at UGent.be]
References:
Tarnaud T, Joseph W, Martens L, Tanghe E. (2019). Computational Modeling of Ultrasonic Subthalamic Nucleus Stimulation. IEEE transactions on bio-medical engineering. 66 [PubMed]