Model Concept: Parkinson's

A progressive nervous disease associated with the loss of dopaminergic (dopamine producing) brain cells in the substantia nigra. Symptoms include hypokinesia (reduced movement), bradykinesia (slowing of movement), partial facial paralysis, peculiarity of gait and posture, and weakness, and rigidity, sometimes combined with rest tremor and postural changes.

  1. A basal ganglia model of aberrant learning (Ursino et al. 2018)
  2. A dynamical model of the basal ganglia (Leblois et al 2006)
  3. A neural model of Parkinson`s disease (Cutsuridis and Perantonis 2006, Cutsuridis 2006, 2007)
  4. A systems model of Parkinson’s disease using biochemical systems theory (Sasidharakurup et al. 2017)
  5. Activity patterns in a subthalamopallidal network of the basal ganglia model (Terman et al 2002)
  6. Adaptive dual control of deep brain stimulation in Parkinsons disease simulations (Grado et al 2018)
  7. AP initiation, propagation, and cortical invasion in a Layer 5 pyramidal cell (Anderson et 2018)
  8. Basal Ganglia and Levodopa Pharmacodynamics model for parameter estimation in PD (Ursino et al 2020)
  9. Basal ganglia motor function and the inverse kinematics calculation (Salimi-Badr et al 2017)
  10. Basal ganglia network model of subthalamic deep brain stimulation (Hahn and McIntyre 2010)
  11. Basal ganglia-thalamic network model for deep brain stimulation (So et al. 2012)
  12. Basal ganglia-thalamocortical loop model of action selection (Humphries and Gurney 2002)
  13. Biochemical Systems Theory Model of TNFa related pathways (Sasidharakurup and Diwakar 2020)
  14. Biologically Constrained Basal Ganglia model (BCBG model) (Lienard, Girard 2014)
  15. Biophysical basis of Subthalamic LFPs Recorded from DBS electrodes (Maling et al 2018)
  16. Cognitive and motor cortico-basal ganglia interactions during decision making (Guthrie et al 2013)
  17. Composite spiking network/neural field model of Parkinsons (Kerr et al 2013)
  18. Computational modeling of ultrasonic Subthalamic Nucleus stimulation (Tarnaud et al 2019)
  19. Computational Modelling of TNFalpha Pathway in Parkinson's Disease (Sasidharakurup et al 2019)
  20. Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
  21. Cortex-Basal Ganglia-Thalamus network model (Kumaravelu et al. 2016)
  22. Cortical Basal Ganglia Network Model during Closed-loop DBS (Fleming et al 2020)
  23. Cortical oscillations and the basal ganglia (Fountas & Shanahan 2017)
  24. Cortico - Basal Ganglia Loop (Mulcahy et al 2020)
  25. D2 dopamine receptor modulation of interneuronal activity (Maurice et al. 2004)
  26. DBS of a multi-compartment model of subthalamic nucleus projection neurons (Miocinovic et al. 2006)
  27. Dopamine-modulated medium spiny neuron, reduced model (Humphries et al. 2009)
  28. Dynamic dopamine modulation in the basal ganglia: Learning in Parkinson (Frank et al 2004,2005)
  29. Excessive beta oscillations in Parkinson's disease (Pavlides et al. 2015)
  30. Excitotoxic loss of dopaminergic cells in PD (Muddapu et al 2019)
  31. Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)
  32. FS Striatal interneuron: K currents solve signal-to-noise problems (Kotaleski et al 2006)
  33. Globus pallidus multi-compartmental model neuron with realistic morphology (Gunay et al. 2008)
  34. GP Neuron, somatic and dendritic phase response curves (Schultheiss et al. 2011)
  35. GPi/GPe neuron models (Johnson and McIntyre 2008)
  36. High frequency stimulation of the Subthalamic Nucleus (Rubin and Terman 2004)
  37. Investigation of different targets in deep brain stimulation for Parkinson`s (Pirini et al. 2009)
  38. Levodopa-Induced Toxicity in Parkinson's Disease (Muddapu et al, 2022)
  39. Mechanisms for pattern specificity of DBS in Parkinson's disease (Velarde et al 2017)
  40. Multiscale model of excitotoxicity in PD (Muddapu and Chakravarthy 2020)
  41. Nav1.6 sodium channel model in globus pallidus neurons (Mercer et al. 2007)
  42. Network model of movement disorders (Yousif et al 2020)
  43. Optimal deep brain stimulation of the subthalamic nucleus-a computational study (Feng et al. 2007)
  44. Phase response curve of a globus pallidal neuron (Fujita et al. 2011)
  45. Population-level model of the basal ganglia and action selection (Gurney et al 2001, 2004)
  46. Prefrontal–striatal Parkinsons comp. model of multicue category learning (Moustafa and Gluck 2011)
  47. Rejuvenation model of dopamine neuron (Chan et al. 2007)
  48. Roles of subthalamic nucleus and DBS in reinforcement conflict-based decision making (Frank 2006)
  49. Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)
  50. Single-cell comprehensive biophysical model of SN pars compacta (Muddapu & Chakravarthy 2021)
  51. Spiking neuron model of the basal ganglia (Humphries et al 2006)
  52. Striatal GABAergic microcircuit, dopamine-modulated cell assemblies (Humphries et al. 2009)
  53. Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
  54. Study of augmented Rubin and Terman 2004 deep brain stim. model in Parkinsons (Pascual et al. 2006)
  55. Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
  56. Thalamic transformation of pallidal input (Hadipour-Niktarash 2006)
  57. The STN-GPe network; subthalamic nucleus, prototypic GPe, and arkypallidal GPe neurons (Kitano 2023)
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