This study investigates the role of feedforward and feedback inhibition in maintaining the balance between D1 and D2 MSNs of the striatum. The synchronized firing of FSIs are found to be critical in this mechanism and specifically the gap junction connections between FSIs.
Model Type: Realistic Network
Simulation Environment: GENESIS
Damodaran S, Evans RC, Blackwell KT. (2014). Synchronized firing of fast-spiking interneurons is critical to maintain balanced firing between direct and indirect pathway neurons of the striatum. Journal of neurophysiology. 111 [PubMed]