We investigated how changes in ionic conductances alter the phase response curve (PRC) of a globus pallidal (GP) neuron and stability of a synchronous activity of a GP network, using a single-compartmental conductance-based neuron model. The results showed the PRC and the stability were influenced by changes in the persistent sodium current, the Kv3 potassium, the M-type potassium and the calcium-dependent potassium current.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Globus pallidus neuron
Currents: I Na,p; I Na,t; I A; I M; I h; I K,Ca; I Calcium; I A, slow; KCNQ1
Transmitters: Ions
Model Concept(s): Synchronization; Parkinson's; Phase Response Curves
Simulation Environment: NEURON
Implementer(s): Kitano, Katsunori [kkt23219 at is.ritsumei.ac.jp]
References:
Fujita T, Fukai T, Kitano K. (2012). Influences of membrane properties on phase response curve and synchronization stability in a model globus pallidus neuron. Journal of computational neuroscience. 32 [PubMed]