A basal ganglia model of aberrant learning (Ursino et al. 2018)

A comprehensive, biologically inspired neurocomputational model of action selection in the Basal Ganglia allows simulation of dopamine induced aberrant learning in Parkinsonian subjects. In particular, the model simulates the Alternate Finger Tapping motor task as an indicator of bradykinesia.

Model Type: Connectionist Network

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell

Receptors: D1; D2; Cholinergic Receptors

Transmitters: Dopamine; Acetylcholine

Model Concept(s): Parkinson's; Synaptic Plasticity; Long-term Synaptic Plasticity

Simulation Environment: MATLAB

Implementer(s): Ursino, Mauro [mauro.ursino at unibo.it]; Baston, Chiara [chiara.baston at unibo.it]


Ursino M, Baston C. (2018). Aberrant learning in Parkinson's disease: A neurocomputational study on bradykinesia. The European journal of neuroscience. 47 [PubMed]

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