A comprehensive, biologically inspired neurocomputational model of action selection in the Basal Ganglia allows simulation of dopamine induced aberrant learning in Parkinsonian subjects. In particular, the model simulates the Alternate Finger Tapping motor task as an indicator of bradykinesia.
Model Type: Connectionist Network
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell
Receptors: D1; D2; Cholinergic Receptors
Transmitters: Dopamine; Acetylcholine
Model Concept(s): Parkinson's; Synaptic Plasticity; Long-term Synaptic Plasticity
Simulation Environment: MATLAB
Implementer(s): Ursino, Mauro [mauro.ursino at unibo.it]; Baston, Chiara [chiara.baston at unibo.it]
References:
Ursino M, Baston C. (2018). Aberrant learning in Parkinson's disease: A neurocomputational study on bradykinesia. The European journal of neuroscience. 47 [PubMed]