A systems model of Parkinson’s disease using biochemical systems theory (Sasidharakurup et al. 2017)

Major pathways involving in Parkinson's disease (PD) such as alphasynuclein aggregation, dopamine synthesis, lewy body formation, tau phosphorylation, parkin, and apoptosis were modeled using stochastic differential equations. Pathways were modeled and simulated using the biochemical pathway visualization program CellDesigner, a modeling tool for gene-regulatory and biochemical networks that support graphical notation and listing of symbols. The model allows a qualitative analysis of PD and a key signalling pathways for evaluating PD treatment conditions relating pathophysiology to molecular concentration changes recorded in experiments.

Model Type: Molecular Network

Region(s) or Organism(s): Generic

Transmitters: Dopamine

Model Concept(s): Signaling pathways; Pathophysiology; Parkinson's

Simulation Environment: CellDesigner

Implementer(s): Sasidharakurup, Hemalatha [hemalathas at am.amrita.edu]; Diwakar, Shyam [shyam at amrita.edu]


Sasidharakurup H, Melethadathil N, Nair B, Diwakar S. (2017). A Systems Model of Parkinson's Disease Using Biochemical Systems Theory. Omics : a journal of integrative biology. 21 [PubMed]

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