Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)

"… Recently, a lot of interest has been devoted to desynchronizing delayed feedback deep brain stimulation (DBS). ... This study explores the action of delayed feedback stimulation on partially synchronized oscillatory dynamics, similar to what one observes experimentally in parkinsonian patients. …" Implemented by Andrey Dovzhenok, to whom questions should be addressed.

Model Type: Realistic Network

Region(s) or Organism(s): Basal ganglia

Cell Type(s): Subthalamus nucleus projection neuron; Globus pallidus neuron

Currents: I Na,t; I T low threshold; I K; I_AHP; I Ca,p

Model Concept(s): Synchronization; Parkinson's; Deep brain stimulation

Simulation Environment: XPPAUT; MATLAB

Implementer(s): Dovzhenok, Andrey [andrey.dovzhenok at]


Dovzhenok A, Park C, Worth RM, Rubchinsky LL. (2013). Failure of delayed feedback deep brain stimulation for intermittent pathological synchronization in Parkinson's disease. PloS one. 8 [PubMed]

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