Failure of Deep Brain Stimulation in a basal ganglia neuronal network model (Dovzhenok et al. 2013)


DBS_Dovzhenoketal2013/tenStim1electr.ode

a1 0.9
ab -30
abg -20
alpha 5
alphag 2.
beta 1
betag 0.14
C1 1
Cn 0.04
deltahg 0.1
deltang 0.3
eps 5e-005
epsg 0.0055
fr 0.01
gahp 9
gahpg 30
gca 0.5
gcag 0.1
gk 40
gkg 30
gl 2.25
glg 0.1
gna 50
gnag 120
gsyn 0.8
gsyng 0.4
gsyngg 0
gt 0.5
gtg 0.5
i 0
i1 0
iapp 6
Igpe 0.
Istn 10.
k1 15
k1g 30
ka 0.33
kca 22.5
kcag 3
Kn 2
kr 2
krg -2
ks1g 2
ksg 2
kt -7.8
phi 5
phig 1
phir 2
rho1 0.5
rsig -0.07
rth 0.25
sh 3.1
shg -12
sigmah 3
sigmahg -12
sigmamg 10
sigman 26
sigmang 14
sigmar 2.2
sm 15
sn -8
sng -12
ss 2
ssca 8
t0 500
tauh0 1
tauh0g 0.05
tauh1 500
tauh1g 0.27
taun0 1
taun0g 0.05
taun1 100
taun1g 0.27
taur0 7.1
taur1 17.5
taurg 30
th 0.05
thetah -39
thetahg -58
thetam 30
thetamg -37
thetan -32
thetang -50
thetar -67
thetarg -70
thetas 39
thetas1g -35
thetasg -57
thetat -63
thh 57
thhg -40
thn 80
thng -40
thr -68
tn 1
vca 140
vcag 120
vk -80
vkg -80
vl -60
vlg -55
vna 55
vnag 55
vsyn -100
vsyng 0
vsyngg -80
w1 0.3
xp 1

DBS_Dovzhenoketal2013/tenStim2electr_v1.ode

a1 0.9
ab -30.
abg -20
alpha 5
alphag 2.
beta 1.
betag 0.14
Cn 0.04
deltahg 0.1
deltang 0.3
eps 5e-05
epsg 0.0055
fr 0.01
gahp 9.
gahpg 30.
gca 0.5
gcag 0.1
gk 40.
gkg 30.
gl 2.25
glg 0.1
gna 50.
gnag 120.
gsyn 1.3
gsyng 0.4
gsyngg 0.0
gt 0.5
gtg 0.5
i 0.
i1 0.
iapp 5.
Igpe 0.
Istn 10.
k1 15.
k1g 30.
ka 0.33
kca 22.5
kcag 3.
Kn 40.
kr 2.
krg -2.
ks1g 2.
ksg 2.
kt -7.8
phi 5.
phig 1.
phir 2.
rho1 0.5
rsig -.07
rth 0.25
sh 3.1
shg -12.
sigmah 3.
sigmahg -12.
sigmamg 10.
sigman 26.
sigmang 14.
sigmar 2.2
sm 15
sn -8.
sng -12.
ss 2.
ssca 8.
t0 1000
tauh0 1.
tauh0g 0.05
tauh1 500
tauh1g 0.27
taun0 1.
taun0g 0.05
taun1 100.
taun1g 0.27
taur0 7.1
taur1 17.5
taurg 30.
th 0.05
thetah -39.
thetahg -58.
thetam 30
thetamg -37.
thetan -32.
thetang -50.
thetar -67.
thetarg -70.
thetas 39.
thetas1g -35.
thetasg -57.
thetat -63.
thh 57.
thhg -40.
thn 80.
thng -40.
thr -68
tn 1.
vca 140.
vcag 120.
vk -80.
vkg -80.
vl -60.
vlg -55.
vna 55.
vnag 55.
vsyn -100.
vsyng 0
vsyngg -80.
w1 0.3
w2 0.
xp 1.

DBS_Dovzhenoketal2013/tenStim2electr_v2.ode

a1 0.9
ab -30.
abg -20
alpha 5
alphag 2.
beta 1.
betag 0.14
Cn 0.04
deltahg 0.1
deltang 0.3
eps 5e-05
epsg 0.0055
fr 0.01
gahp 9.
gahpg 30.
gca 0.5
gcag 0.1
gk 40.
gkg 30.
gl 2.25
glg 0.1
gna 50.
gnag 120.
gsyn 1.4
gsyng 0.4
gsyngg 0.0
gt 0.5
gtg 0.5
i 0.
i1 0.
iapp 8
Igpe 0.
Istn 10.
k1 15.
k1g 30.
ka 0.33
kca 22.5
kcag 3.
Kn 60
kr 2.
krg -2.
ks1g 2.
ksg 2.
kt -7.8
phi 5.
phig 1.
phir 2.
rho1 0.5
rsig -.07
rth 0.25
sh 3.1
shg -12.
sigmah 3.
sigmahg -12.
sigmamg 10.
sigman 26.
sigmang 14.
sigmar 2.2
sm 15
sn -8.
sng -12.
ss 2.
ssca 8.
t0 1000
tauh0 1.
tauh0g 0.05
tauh1 500
tauh1g 0.27
taun0 1.
taun0g 0.05
taun1 100.
taun1g 0.27
taur0 7.1
taur1 17.5
taurg 30.
th 0.05
thetah -39.
thetahg -58.
thetam 30
thetamg -37.
thetan -32.
thetang -50.
thetar -67.
thetarg -70.
thetas 39.
thetas1g -35.
thetasg -57.
thetat -63.
thh 57.
thhg -40.
thn 80.
thng -40.
thr -68
tn 1.
vca 140.
vcag 120.
vk -80.
vkg -80.
vl -60.
vlg -55.
vna 55.
vnag 55.
vsyn -100.
vsyng 0
vsyngg -80.
w1 0.3
w2 0
xp 1.

DBS_Dovzhenoketal2013/tenStim3electr_v1.ode

a1 0.9
ab -30.
abg -20
alpha 5
alphag 2.
beta 1.
betag 0.14
Cn 0.04
deltahg 0.1
deltang 0.3
eps 5e-05
epsg 0.0055
fr 0.01
gahp 9.
gahpg 30.
gca 0.5
gcag 0.1
gk 40.
gkg 30.
gl 2.25
glg 0.1
gna 50.
gnag 120.
gsyn 1.4
gsyng 0.4
gsyngg 0.0
gt 0.5
gtg 0.5
i 0.
i1 0.
iapp 8
Igpe 0.
Istn 10.
k1 15.
k1g 30.
ka 0.33
kca 22.5
kcag 3.
Kn 60
kr 2.
krg -2.
ks1g 2.
ksg 2.
kt -7.8
phi 5.
phig 1.
phir 2.
rho1 0.5
rsig -.07
rth 0.25
sh 3.1
shg -12.
sigmah 3.
sigmahg -12.
sigmamg 10.
sigman 26.
sigmang 14.
sigmar 2.2
sm 15
sn -8.
sng -12.
ss 2.
ssca 8.
t0 1000
tauh0 1.
tauh0g 0.05
tauh1 500
tauh1g 0.27
taun0 1.
taun0g 0.05
taun1 100.
taun1g 0.27
taur0 7.1
taur1 17.5
taurg 30.
th 0.05
thetah -39.
thetahg -58.
thetam 30
thetamg -37.
thetan -32.
thetang -50.
thetar -67.
thetarg -70.
thetas 39.
thetas1g -35.
thetasg -57.
thetat -63.
thh 57.
thhg -40.
thn 80.
thng -40.
thr -68
tn 1.
vca 140.
vcag 120.
vk -80.
vkg -80.
vl -60.
vlg -55.
vna 55.
vnag 55.
vsyn -100.
vsyng 0
vsyngg -80.
w1 0.3
w2 0
xp 1.

DBS_Dovzhenoketal2013/tenStim3electr_v2.ode

a1 0.9
ab -30.
abg -20
alpha 5
alphag 2.
beta 1.
betag 0.14
Cn 0.04
deltahg 0.1
deltang 0.3
eps 5e-05
epsg 0.0055
fr 0.01
gahp 9.
gahpg 30.
gca 0.5
gcag 0.1
gk 40.
gkg 30.
gl 2.25
glg 0.1
gna 50.
gnag 120.
gsyn 1.4
gsyng 0.4
gsyngg 0.0
gt 0.5
gtg 0.5
i 0.
i1 0.
iapp 8
Igpe 0.
Istn 10.
k1 15.
k1g 30.
ka 0.33
kca 22.5
kcag 3.
Kn 60
kr 2.
krg -2.
ks1g 2.
ksg 2.
kt -7.8
phi 5.
phig 1.
phir 2.
rho1 0.5
rsig -.07
rth 0.25
sh 3.1
shg -12.
sigmah 3.
sigmahg -12.
sigmamg 10.
sigman 26.
sigmang 14.
sigmar 2.2
sm 15
sn -8.
sng -12.
ss 2.
ssca 8.
t0 1000
tauh0 1.
tauh0g 0.05
tauh1 500
tauh1g 0.27
taun0 1.
taun0g 0.05
taun1 100.
taun1g 0.27
taur0 7.1
taur1 17.5
taurg 30.
th 0.05
thetah -39.
thetahg -58.
thetam 30
thetamg -37.
thetan -32.
thetang -50.
thetar -67.
thetarg -70.
thetas 39.
thetas1g -35.
thetasg -57.
thetat -63.
thh 57.
thhg -40.
thn 80.
thng -40.
thr -68
tn 1.
vca 140.
vcag 120.
vk -80.
vkg -80.
vl -60.
vlg -55.
vna 55.
vnag 55.
vsyn -100.
vsyng 0
vsyngg -80.
w1 0.3
w2 0
xp 1.
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