Model Concept: Detailed Neuronal Models

A detailed model of a real neuron, with as-accurate-as-possible representations of the cell morphology and membrane properties.

  1. 3D model of the olfactory bulb (Migliore et al. 2014)
  2. A detailed and fast model of extracellular recordings (Camunas-Mesa & Qurioga 2013)
  3. A detailed Purkinje cell model (Masoli et al 2015)
  4. A model for recurrent spreading depolarizations (Conte et al. 2017)
  5. A model of ASIC1a and synaptic cleft pH modulating wind-up in wide dynamic range neurons (Delrocq)
  6. A model of the femur-tibia control system in stick insects (Stein et al. 2008)
  7. A model of ventral Hippocampal CA1 pyramidal neurons of Tg2576 AD mice (Spoleti et al. 2021)
  8. A multi-compartment model for interneurons in the dLGN (Halnes et al. 2011)
  9. A set of reduced models of layer 5 pyramidal neurons (Bahl et al. 2012)
  10. A simplified cerebellar Purkinje neuron (the PPR model) (Brown et al. 2011)
  11. Acetylcholine Boosts Dendritic NMDA Spikes in a CA3 Pyramidal Neuron Model (Humphries et al., 2021)
  12. Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003)
  13. Active dendrites shape signaling microdomains in hippocampal neurons (Basak & Narayanan 2018)
  14. Adaptive robotic control driven by a versatile spiking cerebellar network (Casellato et al. 2014)
  15. Age-dependent excitability of CA1 pyramidal neurons in APPPS1 Alzheimer's model (Vitale et al 2021)
  16. Alcohol action in a detailed Purkinje neuron model and an efficient simplified model (Forrest 2015)
  17. Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)
  18. AMPA receptor trafficking and its role in heterosynaptic plasticity (Antunes et al 2018)
  19. Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)
  20. AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)
  21. Biophysically detailed model of somatosensory thalamocortical circuit
  22. Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. 2018)
  23. CA1 oriens alveus interneurons: signaling properties (Minneci et al. 2007)
  24. CA1 pyr cell: Inhibitory modulation of spatial selectivity+phase precession (Grienberger et al 2017)
  25. CA1 pyramidal neuron (Migliore et al 1999)
  26. CA1 pyramidal neuron synaptic integration (Jarsky et al. 2005)
  27. CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)
  28. CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)
  29. CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)
  30. CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)
  31. CA1 pyramidal neuron: conditional boosting of dendritic APs (Watanabe et al 2002)
  32. CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)
  33. CA1 pyramidal neuron: dendritic spike initiation (Gasparini et al 2004)
  34. CA1 pyramidal neuron: effects of Ih on distal inputs (Migliore et al 2004)
  35. CA1 pyramidal neuron: effects of Lamotrigine on dendritic excitability (Poolos et al 2002)
  36. CA1 pyramidal neuron: functional significance of axonal Kv7 channels (Shah et al. 2008)
  37. CA1 pyramidal neuron: h channel-dependent deficit of theta oscill. resonance (Marcelin et al. 2008)
  38. CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
  39. CA1 pyramidal neuron: integration of subthreshold inputs from PP and SC (Migliore 2003)
  40. CA1 pyramidal neuron: Persistent Na current mediates steep synaptic amplification (Hsu et al 2018)
  41. CA1 pyramidal neuron: rebound spiking (Ascoli et al.2010)
  42. Ca1 pyramidal neuron: reduction model (Marasco et al. 2012)
  43. CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)
  44. CA1 pyramidal neuron: signal propagation in oblique dendrites (Migliore et al 2005)
  45. CA1 Pyramidal Neuron: slow Na+ inactivation (Migliore 1996)
  46. CA1 pyramidal neurons: binding properties and the magical number 7 (Migliore et al. 2008)
  47. CA1 pyramidal neurons: effect of external electric field from power lines (Cavarretta et al. 2014)
  48. CA1 pyramidal neurons: effects of a Kv7.2 mutation (Miceli et al. 2009)
  49. CA1 pyramidal neurons: effects of Alzheimer (Culmone and Migliore 2012)
  50. CA1 pyramidal populations after high frequency head impacts (Chapman, et al., 2023)
  51. CA1 pyramidal: Stochastic amplification of KCa in Ca2+ microdomains (Stanley et al. 2011)
  52. CA1 stratum radiatum interneuron multicompartmental model (Katona et al. 2011)
  53. CA3 pyramidal neuron (Lazarewicz et al 2002)
  54. CA3 Pyramidal Neuron (Migliore et al 1995)
  55. CA3 pyramidal neuron (Safiulina et al. 2010)
  56. CA3 pyramidal neuron: firing properties (Hemond et al. 2008)
  57. Calcium dynamics depend on dendritic diameters (Anwar et al. 2014)
  58. CaMKII system exhibiting bistability with respect to calcium (Graupner and Brunel 2007)
  59. Cellular classes revealed by heartbeat-related modulation of extracellular APs (Mosher et al 2020)
  60. Cerebellar gain and timing control model (Yamazaki & Tanaka 2007)(Yamazaki & Nagao 2012)
  61. Cerebellar Nucleus Neuron (Steuber, Schultheiss, Silver, De Schutter & Jaeger, 2010)
  62. Cerebellar purkinje cell (De Schutter and Bower 1994)
  63. Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)
  64. Channel density variability among CA1 neurons (Migliore et al. 2018)
  65. Chirp stimulus responses in a morphologically realistic model (Narayanan and Johnston, 2007)
  66. Cholinergic modulation of resting state networks (Sanda et al., accepted)
  67. Circadian rhythmicity shapes astrocyte morphology and neuronal function in CA1 (McCauley et al 2020)
  68. Coincidence detection in avian brainstem (Simon et al 1999)
  69. Combining modeling, deep learning for MEA neuron localization, classification (Buccino et al 2018)
  70. Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)
  71. Computational model of bladder small DRG neuron soma (Mandge & Manchanda 2018)
  72. Computer models of corticospinal neurons replicate in vitro dynamics (Neymotin et al. 2017)
  73. Correcting space clamp in dendrites (Schaefer et al. 2003 and 2007)
  74. Cortical Layer 5b pyr. cell with [Na+]i mechanisms, from Hay et al 2011 (Zylbertal et al 2017)
  75. Cortical network model of posttraumatic epileptogenesis (Bush et al 1999)
  76. Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)
  77. Dendritic Na+ spike initiation and backpropagation of APs in active dendrites (Nevian et al. 2007)
  78. Dendritic signals command firing dynamics in a Cerebellar Purkinje Cell model (Genet et al. 2010)
  79. Dendritica (Vetter et al 2001)
  80. Dentate Basket Cell: spatial summation of inhibitory synaptic inputs (Bartos et al 2001)
  81. Dentate granule cell: mAHP & sAHP; SK & Kv7/M channels (Mateos-Aparicio et al., 2014)
  82. Detailed passive cable model of Dentate Gyrus Basket Cells (Norenberg et al. 2010)
  83. DG adult-born granule cell: nonlinear a5-GABAARs control AP firing (Lodge et al, 2021)
  84. Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001)
  85. Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs (vitale et al., 2023)
  86. Differential modulation of pattern and rate in a dopamine neuron model (Canavier and Landry 2006)
  87. Dorsal root ganglion (DRG) neuronal model (Amir, Devor 2003)
  88. Double cable myelinated axon (Layer 5 pyramidal neuron; Cohen et al 2020)
  89. Effects of electric fields on cognitive functions (Migliore et al 2016)
  90. Effects of neural morphology on global and focal NMDA-spikes (Poleg-Polsky 2015)
  91. Electrical compartmentalization in neurons (Wybo et al 2019)
  92. Electrotonic transform and EPSCs for WT and Q175+/- spiny projection neurons (Goodliffe et al 2018)
  93. Emergent properties of networks of biological signaling pathways (Bhalla, Iyengar 1999)
  94. Engaging distinct oscillatory neocortical circuits (Vierling-Claassen et al. 2010)
  95. Excitability of PFC Basal Dendrites (Acker and Antic 2009)
  96. Excitatory synaptic interactions in pyramidal neuron dendrites (Behabadi et al. 2012)
  97. Fast AMPA receptor signaling (Geiger et al 1997)
  98. Fast Spiking Basket cells (Tzilivaki et al 2019)
  99. FHF2KO and Wild-Type Mouse Cardiomyocyte Strands (Park et al 2020)
  100. Firing neocortical layer V pyramidal neuron (Reetz et al. 2014; Stadler et al. 2014)
  101. Four-pathway phenomenological synaptic plasticity model (Ebner et al. 2019)
  102. FS Striatal interneuron: K currents solve signal-to-noise problems (Kotaleski et al 2006)
  103. Gap junction coupled network of striatal fast spiking interneurons (Hjorth et al. 2009)
  104. Gating of steering signals through phasic modulation of reticulospinal neurons (Kozlov et al. 2014)
  105. Generation of granule cell dendritic morphology (Schneider et al. 2014)
  106. Glial voltage dynamics driven by Kir & K2P currents (Janjic et al 2023)
  107. Global and multiplexed dendritic computations under in vivo-like conditions (Ujfalussy et al 2018)
  108. Globus pallidus multi-compartmental model neuron with realistic morphology (Gunay et al. 2008)
  109. Globus pallidus neuron models with differing dendritic Na channel expression (Edgerton et al., 2010)
  110. Glutamate mediated dendritic and somatic plateau potentials in cortical L5 pyr cells (Gao et al '20)
  111. Heterogeneous Purkinje Cell model (Cirtala et al., accepted)
  112. Hippocampal CA3 thorny and a-thorny principal neuron models (Linaro et al in review)
  113. Human Cortical L5 Pyramidal Cell (Rich et al. 2021)
  114. Human layer 2/3 cortical microcircuits in health and depression (Yao et al, 2022)
  115. Impact of dendritic atrophy on intrinsic and synaptic excitability (Narayanan & Chattarji, 2010)
  116. Impact of dendritic size and topology on pyramidal cell burst firing (van Elburg and van Ooyen 2010)
  117. Impact on backpropagation of the spatial heterogeneity of sodium channel kinetics in the axon initial segment (Barlow et al., 2024)
  118. Impedance spectrum in cortical tissue: implications for LFP signal propagation (Miceli et al. 2017)
  119. Influence of dendritic structure on neocortical neuron firing patterns (Mainen and Sejnowski 1996)
  120. Interacting synaptic conductances during, distorting, voltage clamp (Poleg-Polsky and Diamond 2011)
  121. Interneuron Specific 3 Interneuron Model (Guet-McCreight et al, 2016)
  122. Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)
  123. Intrinsic sensory neurons of the gut (Chambers et al. 2014)
  124. KV1 channel governs cerebellar output to thalamus (Ovsepian et al. 2013)
  125. L5 PFC pyramidal neurons (Papoutsi et al. 2017)
  126. L5b PC model constrained for BAC firing and perisomatic current step firing (Hay et al., 2011)
  127. Lamprey spinal CPG neuron (Huss et al. 2007)
  128. Large scale model of the olfactory bulb (Yu et al., 2013)
  129. Large scale neocortical model for PGENESIS (Crone et al 2019)
  130. Layer V PFC pyramidal neuron used to study persistent activity (Sidiropoulou & Poirazi 2012)
  131. Leech Heart (HE) Motor Neuron conductances contributions to NN activity (Lamb & Calabrese 2013)
  132. Leech Mechanosensory Neurons: Synaptic Facilitation by Reflected APs (Baccus 1998)
  133. LGMD - ON excitation to dendritic field C
  134. LGMD impedance (Dewell & Gabbiani 2019)
  135. Library of biophysically detailed striatal projection neurons (Lindroos and Hellgren Kotaleski 2020)
  136. Linear vs non-linear integration in CA1 oblique dendrites (Gómez González et al. 2011)
  137. Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)
  138. Low Threshold Calcium Currents in TC cells (Destexhe et al 1998) (Brian)
  139. MCCAIS model (multicompartmental cooperative AIS) (Öz et al 2015)
  140. Mechanisms for pattern specificity of DBS in Parkinson's disease (Velarde et al 2017)
  141. Mechanisms of fast rhythmic bursting in a layer 2/3 cortical neuron (Traub et al 2003)
  142. Mechanisms of very fast oscillations in axon networks coupled by gap junctions (Munro, Borgers 2010)
  143. Mechanisms underlying subunit independence in pyramidal neuron dendrites (Behabadi and Mel 2014)
  144. Membrane electrical properties of mouse CA1 pyramidal cells during strong inputs (Bianchi et al 22)
  145. Microcircuits of L5 thick tufted pyramidal cells (Hay & Segev 2015)
  146. Mirror Neuron (Antunes et al 2017)
  147. Model of arrhythmias in a cardiac cells network (Casaleggio et al. 2014)
  148. Modeling interactions in Aplysia neuron R15 (Yu et al 2004)
  149. Modeling temperature changes in AMPAR kinetics (Postlethwaite et al 2007)
  150. Modelling platform of the cochlear nucleus and other auditory circuits (Manis & Compagnola 2018)
  151. Molecular layer interneurons in cerebellum encode valence in associative learning (Ma et al 2020)
  152. Multi-comp. CA1 O-LM interneuron model with varying dendritic Ih distributions (Sekulic et al 2015)
  153. Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)
  154. Multiplexed coding in Purkinje neuron dendrites (Zang and De Schutter 2021)
  155. Multiscale model of excitotoxicity in PD (Muddapu and Chakravarthy 2020)
  156. MyFirstNEURON (Houweling, Sejnowski 1997)
  157. NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)
  158. Neocort. pyramidal cells subthreshold somatic voltage controls spike propagation (Munro Kopell 2012)
  159. Nigral dopaminergic neurons: effects of ethanol on Ih (Migliore et al. 2008)
  160. Nonlinear dendritic processing in barrel cortex spiny stellate neurons (Lavzin et al. 2012)
  161. Norns - Neural Network Studio (Visser & Van Gils 2014)
  162. Numerical Integration of Izhikevich and HH model neurons (Stewart and Bair 2009)
  163. O-LM interneuron model (Lawrence et al. 2006)
  164. Olfactory bulb mitral and granule cell column formation (Migliore et al. 2007)
  165. Olfactory bulb mitral and granule cell: dendrodendritic microcircuits (Migliore and Shepherd 2008)
  166. Olfactory Computations in Mitral-Granule cell circuits (Migliore & McTavish 2013)
  167. Olfactory Mitral Cell (Bhalla, Bower 1993)
  168. Optical stimulation of a channelrhodopsin-2 positive pyramidal neuron model (Foutz et al 2012)
  169. Paradoxical GABA-mediated excitation (Lewin et al. 2012)
  170. Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells (Lee et al. 2014)
  171. Potjans-Diesmann cortical microcircuit model in NetPyNE (Romaro et al 2021)
  172. Principles of Computational Modelling in Neuroscience (Book) (Sterratt et al. 2011)
  173. Proximal inhibition of Renshaw cells (Bui et al 2005)
  174. Purkinje cell: Synaptic activation predicts voltage control of burst-pause (Masoli & D'Angelo 2017)
  175. Rapid desynchronization of an electrically coupled Golgi cell network (Vervaeke et al. 2010)
  176. Rat LGN Thalamocortical Neuron (Connelly et al 2015, 2016)
  177. Regulation of the firing pattern in dopamine neurons (Komendantov et al 2004)
  178. Rhesus Monkey Layer 3 Pyramidal Neurons: V1 vs PFC (Amatrudo, Weaver et al. 2012)
  179. Rhesus Monkey Layer 3 Pyramidal Neurons: Young vs aged PFC (Coskren et al. 2015)
  180. Rhesus Monkey Young and Aged L3 PFC Pyramidal Neurons (Rumbell et al. 2016)
  181. Salamander retinal ganglian cells: morphology influences firing (Sheasby, Fohlmeister 1999)
  182. Salamander retinal ganglion cell: ion channels (Fohlmeister, Miller 1997)
  183. Schiz.-linked gene effects on intrinsic single-neuron excitability (Maki-Marttunen et al. 2016)
  184. Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)
  185. Shaping NMDA spikes by timed synaptic inhibition on L5PC (Doron et al. 2017)
  186. Single compartment Dorsal Lateral Medium Spiny Neuron w/ NMDA and AMPA (Biddell and Johnson 2013)
  187. Single-cell comprehensive biophysical model of SN pars compacta (Muddapu & Chakravarthy 2021)
  188. Sloppy morphological tuning in identified neurons of the crustacean STG (Otopalik et al 2017)
  189. Smoothing of, and parameter estimation from, noisy biophysical recordings (Huys & Paninski 2009)
  190. Space clamp problems in neurons with voltage-gated conductances (Bar-Yehuda and Korngreen 2008)
  191. Spatial summation of excitatory and inhibitory inputs in pyramidal neurons (Hao et al. 2010)
  192. Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995)
  193. Spike propagation and bouton activation in terminal arborizations (Luscher, Shiner 1990)
  194. Spike-timing dependent inhibitory plasticity for gating bAPs (Wilmes et al 2017)
  195. Spiking GridPlaceMap model (Pilly & Grossberg, PLoS One, 2013)
  196. Spine fusion and branching affects synaptic response (Rusakov et al 1996, 1997)
  197. Spiny Projection Neuron Ca2+ based plasticity is robust to in vivo spike train (Dorman&Blackwell)
  198. Stochastic 3D model of neonatal rat spinal motoneuron (Ostroumov 2007)
  199. Stochastic ion channels and neuronal morphology (Cannon et al. 2010)
  200. Stochastic model of the olfactory cilium transduction and adaptation (Antunes et al 2014)
  201. Stoney vs Histed: Quantifying spatial effects of intracortical microstims (Kumaravelu et al 2022)
  202. Striatal D1R medium spiny neuron, including a subcellular DA cascade (Lindroos et al 2018)
  203. Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)
  204. Striatal Spiny Projection Neuron, inhibition enhances spatial specificity (Dorman et al 2018)
  205. Striatum D1 Striosome and Matrix Upstates (Prager et al., 2020)
  206. Synaptic integration in a model of granule cells (Gabbiani et al 1994)
  207. Synaptic integration in tuft dendrites of layer 5 pyramidal neurons (Larkum et al. 2009)
  208. Synaptic strengths are critical in creating the proper output phasing in a CPG (Gunay et al 2019)
  209. Synchronicity of fast-spiking interneurons balances medium-spiny neurons (Damodaran et al. 2014)
  210. Synchronization in a realistic model of CA1 pyramidal neurons (Fiasconaro and Migliore 2024)
  211. Systematic integration of data into multi-scale models of mouse primary V1 (Billeh et al 2020)
  212. Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)
  213. Thalamocortical relay neuron models constrained by experiment and optimization (Iavarone et al 2019)
  214. The electrodiffusive neuron-extracellular-glia (edNEG) model (Sætra et al. 2021)
  215. The electrodiffusive Pinsky-Rinzel (edPR) model (Sætra et al., 2020)
  216. The neocortical microcircuit collaboration portal (Markram et al. 2015)
  217. Theta phase precession in a model CA3 place cell (Baker and Olds 2007)
  218. Transfer properties of Neuronal Dendrites (Korogod et al 1998)
  219. Using Strahler's analysis to reduce realistic models (Marasco et al, 2013)
  220. Vertical system (VS) fly cells with biophysics (Dan et al 2018)
  221. Visual physiology of the layer 4 cortical circuit in silico (Arkhipov et al 2018)
  222. Voltage attenuation in CA1 pyramidal neuron dendrites (Golding et al 2005)
  223. Voltage- and Branch-specific Climbing Fiber Responses in Purkinje Cells (Zang et al 2018)
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