CA1 pyramidal neuron synaptic integration (Li and Ascoli 2006, 2008)

The model shows how different input patterns (irregular & asynchronous, irregular & synchronous, regular & asynchronous, regular & synchronous) affect the neuron's output rate when 1000 synapses are distributed in the proximal apical dendritic tree of a hippocampus CA1 pyramidal neuron.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K; I h

Receptors: AMPA; NMDA

Model Concept(s): Detailed Neuronal Models; Synaptic Integration

Simulation Environment: NEURON

Implementer(s): Li, Xiaoshen [xsli2 at yahoo.com]

References:

Li X, Ascoli GA. (2006). Computational simulation of the input-output relationship in hippocampal pyramidal cells. Journal of computational neuroscience. 21 [PubMed]

Li X, Ascoli GA. (2008). Effects of synaptic synchrony on the neuronal input-output relationship. Neural computation. 20 [PubMed]