Dendritic Na+ spike initiation and backpropagation of APs in active dendrites (Nevian et al. 2007)

NEURON model used to create simulations shown in figure 6 of the paper. The model includes two point processes; one for dendritic spike initiation and the other for somatic action potential generation. The effect of filtering by imperfect recording electrode can be examined in somatic and dendritic locations.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I N; I K

Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models

Simulation Environment: NEURON

Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il]

References:

Nevian T, Larkum ME, Polsky A, Schiller J. (2007). Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nature neuroscience. 10 [PubMed]